N-[(E)-4-甲氧基苯乙烯基]苯甲酰胺合成路线 （共 10 条）
反应条件
copper(I) oxide; water; caesium carbonate; 1-n-butyl-3-methylimidazolium hexafluorophosphate; sodium hydroxide; N-methyl-2-(methylamino)ethylamine
T=100°C; 12 h; Inert atmosphereSealed tube;
参考文献
Wang, Jichao; Yin, Xinchi; Wu, Jun; Wu, Datong; Pan, Yuanjiang
Tetrahedron, 2013 , vol. 69, # 48 p. 10463 - 10469
反应条件
1: With [Ru(η4-COD)(η3-methylallyl)2]; dcypb; ytterbium(III) triflate in water; N,N-dimethyl-formamide
T=60°C; 6 h; Inert atmosphere;
2: With triethylamine in water; N,N-dimethyl-formamide
T=110°C; 24 h; Inert atmosphereMolecular sieve; optical yield given as percent destereoselective reaction;
参考文献
Goossen, Lukas J.; Salih, Kifah S. M.; Blanchot, Mathieu
Angewandte Chemie - International Edition, 2008 , vol. 47, # 44 p. 8492 - 8495
反应条件
copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine in tetrahydrofuran
T=80°C; 18 h; Inert atmosphere;
参考文献
Cheung, Chi Wai; Buchwald, Stephen L.
Journal of Organic Chemistry, 2012 , vol. 77, # 17 p. 7526 - 7537
反应条件
1: 56 percent / Ac2O, sodium acetate
2: 94 percent / NaOH / ethanol / 1 h / Heating
3: 73 percent / diethyl ether; acetone / 2 h / 0 °C
4: 40 percent / potassium cyanide / dimethylformamide; ethanol / 6 h / 140 °C
View Scheme
参考文献
Ghosh, Somnath; Datta, Diptendu Bhusan; Sen, Nupur
Synthetic Communications, 1987 , vol. 17, # 3 p. 299 - 308
反应条件
1: 94 percent / NaOH / ethanol / 1 h / Heating
2: 73 percent / diethyl ether; acetone / 2 h / 0 °C
3: 40 percent / potassium cyanide / dimethylformamide; ethanol / 6 h / 140 °C
View Scheme
参考文献
Ghosh, Somnath; Datta, Diptendu Bhusan; Sen, Nupur
Synthetic Communications, 1987 , vol. 17, # 3 p. 299 - 308
反应条件
1: 73 percent / diethyl ether; acetone / 2 h / 0 °C
2: 40 percent / potassium cyanide / dimethylformamide; ethanol / 6 h / 140 °C
View Scheme
参考文献
Ghosh, Somnath; Datta, Diptendu Bhusan; Sen, Nupur
Synthetic Communications, 1987 , vol. 17, # 3 p. 299 - 308
反应条件
1: 56 percent / Ac2O, sodium acetate
2: 94 percent / NaOH / ethanol / 1 h / Heating
3: 73 percent / diethyl ether; acetone / 2 h / 0 °C
4: 40 percent / potassium cyanide / dimethylformamide; ethanol / 6 h / 140 °C
View Scheme
参考文献
Ghosh, Somnath; Datta, Diptendu Bhusan; Sen, Nupur
Synthetic Communications, 1987 , vol. 17, # 3 p. 299 - 308
反应条件
1: Zn, HCl, AcOH / 2 h / Heating
2: 83 percent / NaHCO3 / CH2Cl2 / 25 °C
3: MCPBA / CH2Cl2; diethyl ether / 6 h / -50 - 0 °C
4: 65 percent / CaCO3 / toluene / 5 h / Heating
View Scheme
参考文献
Obrecht, Jurg; Hellberg, Lars; Somanathan, Ratnasamy
Journal of the Chemical Society, Chemical Communications, 1987 , # 16 p. 1219 - 1220
反应条件
1: MCPBA / CH2Cl2; diethyl ether / 6 h / -50 - 0 °C
2: 65 percent / CaCO3 / toluene / 5 h / Heating
View Scheme
参考文献
Obrecht, Jurg; Hellberg, Lars; Somanathan, Ratnasamy
Journal of the Chemical Society, Chemical Communications, 1987 , # 16 p. 1219 - 1220
反应条件
triethylamine
T=110°C; 24 h; Inert atmosphereMolecular sieve; optical yield given as percent de;
参考文献
Goossen, Lukas J.; Blanchot, Mathieu; Salih, Kifah S. M.; Goossen, Kaethe
Synthesis, 2009 , # 13 art. no. Z04009SS, p. 2283 - 2288
