4-(N,N-dimethlyamino)pyridine; EDC monohydrochloride in dichloromethane T=20°C; 12 h; Inert atmosphere;

2,4,6-trimethyl-pyridine Heating;

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / |Inert atmosphere 1.2: 1.5 h / -78 - 20 °C / |Inert atmosphere 2.1: pyridine; thionyl chloride / dichloromethane / 3.17 h / 0 - 20 °C / |Inert atmosphere 3.1: potassium hydroxide / tetrahydrofuran; water / 48 h / 90 °C / |Inert atmosphere 4.1: 4-(N,N-dimethlyamino)pyridine; EDC monohydrochloride / dichloromethane / 12 h / 20 °C / |Inert atmosphere View Scheme

1: pyridine; thionyl chloride / dichloromethane / 3.17 h / 0 - 20 °C / |Inert atmosphere 2: potassium hydroxide / tetrahydrofuran; water / 48 h / 90 °C / |Inert atmosphere 3: 4-(N,N-dimethlyamino)pyridine; EDC monohydrochloride / dichloromethane / 12 h / 20 °C / |Inert atmosphere View Scheme

1: potassium hydroxide / tetrahydrofuran; water / 48 h / 90 °C / |Inert atmosphere 2: 4-(N,N-dimethlyamino)pyridine; EDC monohydrochloride / dichloromethane / 12 h / 20 °C / |Inert atmosphere View Scheme

1: 76 percent / AlCl3 / Ambient temperature 2: 66 percent / sym-collidine / Heating View Scheme

1: 76 percent / AlCl3 / Ambient temperature 2: 66 percent / sym-collidine / Heating View Scheme

暂无反应条件数据

aluminium trichloride in benzene 0.5 h; Ambient temperature;