(6-溴-苯并1,3二氧代-5-基)-乙酸合成路线 （共 13 条）
反应条件
1: aq. NaOH solution
2: benzene; hydrogen chloride
3: ethanol
4: aq.-ethanolic NaOH-solution
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参考文献
Naik; Wheeler
Journal of the Chemical Society, 1938 , p. 1780,1782
反应条件
1.1: SOCl2
2.1: 89.7 percent / aq. Na2CO3 / diethyl ether; benzene / 1 h / 0 - 5 °C
3.1: 86 percent / BF3*Et2O; BH3*THF / tetrahydrofuran / 2.5 h / 70 - 80 °C
4.1: 71 percent / aq. Na2CO3 / diethyl ether / 2 h / 23 - 27 °C
5.1: POCl3 / acetonitrile / 2 h / 80 - 83 °C
5.2: 8 percent / NaBH4 / methanol / 2 h / -78 °C
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参考文献
Hashimoto, Naomi; Miyatani, Kumiko; Ohkita, Keiko; Ohishi, Yoshitaka; Kunitomo, Jun-Ichi; Kawasaki, Ikuo; Yamashita, Masayuki; Ohta, Shunsaku
Heterocycles, 2002 , vol. 57, # 11 p. 2149 - 2161
反应条件
2: ammonia; methanol / 130 °C
3: phosphoryl chloride; toluene
View Scheme
参考文献
Stevens
Journal of the Chemical Society, 1935 , p. 663,667
