(6-溴-苯并1,3二氧代-5-基)-乙酸合成路线 （共 13 条）
反应条件
sulfuric acid 0.5 h; Reflux;
参考文献
Kapadia, Nirav; Harding, Wayne
Tetrahedron, 2013 , vol. 69, # 42 p. 8914 - 8920
参考文献
Stevens
Journal of the Chemical Society, 1935 , p. 663,667
反应条件
bromine; acetic acid
T=23°C; 18 h;
参考文献
Liu, Qi; Ferreira, Eric M.; Stoltz, Brian M.
Journal of Organic Chemistry, 2007 , vol. 72, # 19 p. 7352 - 7358
反应条件
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene in tetrahydrofuran; water
T=20°C; Pinnick oxidation; 0.5 h;
参考文献
Nicolaou, K. C.; Stepan, Antonia F.; Lister, Troy; Li, Ang; Montero, Ana; et al.
Journal of the American Chemical Society, 2008 , vol. 130, p. 13110 - 13119
反应条件
1: With water; sodium hydroxide in ethanol
18 h; Reflux;
2: With hydrogenchloride in ethanol
pH=2;
参考文献
Kukosha, Tatyana; Trufilkina, Nadezhda; Katkevics, Martins
Synlett, 2011 , # 17 p. 2525 - 2528
反应条件
1.1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 18 h / 70 °C
2.1: dimethyl sulfoxide / 0.33 h / 50 - 90 °C
3.1: water; sodium hydroxide / ethanol / 18 h / Reflux
3.2: pH 2
View Scheme
参考文献
Kukosha, Tatyana; Trufilkina, Nadezhda; Katkevics, Martins
Synlett, 2011 , # 17 p. 2525 - 2528
反应条件
1.1: dimethyl sulfoxide / 0.33 h / 50 - 90 °C
2.1: water; sodium hydroxide / ethanol / 18 h / Reflux
2.2: pH 2
View Scheme
参考文献
Kukosha, Tatyana; Trufilkina, Nadezhda; Katkevics, Martins
Synlett, 2011 , # 17 p. 2525 - 2528
参考文献
Girardet
Helvetica Chimica Acta, 1931 , vol. 14, p. 513
反应条件
1: benzene; hydrogen chloride
2: ethanol
3: aq.-ethanolic NaOH-solution
View Scheme
参考文献
Naik; Wheeler
Journal of the Chemical Society, 1938 , p. 1780,1782
反应条件
1: ethanol
2: aq.-ethanolic NaOH-solution
View Scheme
参考文献
Naik; Wheeler
Journal of the Chemical Society, 1938 , p. 1780,1782
