4-(1H-咪唑-1-基)-2-甲基-8-羟基喹啉合成路线 （共 7 条）
反应条件
in 1,4-dioxane
6 h; Heating;
参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Imai, Keisuke; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Katayama, Akira; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1617 - 1630
反应条件
in 1,4-dioxane; chloroform
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6008229 A1, 1999 ;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6008229 A1, 1999 ;
反应条件
1: 81.9 percent / phosphorus oxychloride; N,N-dimethylaniline / 2 h / Heating
2: 70.4 percent / boron tribromide / 2 h / Heating
3: 85.5 percent / dioxane / 6 h / Heating
View Scheme
参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Imai, Keisuke; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Katayama, Akira; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1617 - 1630
反应条件
1: 70.4 percent / boron tribromide / 2 h / Heating
2: 85.5 percent / dioxane / 6 h / Heating
View Scheme
参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Imai, Keisuke; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Katayama, Akira; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1617 - 1630
反应条件
1: 48.7 percent / diphenyl ether; various solvent(s) / 3 h / 235 °C
2: 81.9 percent / phosphorus oxychloride; N,N-dimethylaniline / 2 h / Heating
3: 70.4 percent / boron tribromide / 2 h / Heating
4: 85.5 percent / dioxane / 6 h / Heating
View Scheme
参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Imai, Keisuke; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Katayama, Akira; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1617 - 1630
反应条件
1: 99.8 percent / AcOH / benzene / 8 h / Heating
2: 48.7 percent / diphenyl ether; various solvent(s) / 3 h / 235 °C
3: 81.9 percent / phosphorus oxychloride; N,N-dimethylaniline / 2 h / Heating
4: 70.4 percent / boron tribromide / 2 h / Heating
5: 85.5 percent / dioxane / 6 h / Heating
View Scheme
参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Imai, Keisuke; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Katayama, Akira; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1617 - 1630
