4-(氨基甲基)环己烷羧酸甲酯盐酸盐合成路线 （共 3 条）
反应条件
1: 4-(aminomethyl)cyclohexanecarboxylic acid in methanol
T=5°C; 0.166667 h; Inert atmosphereLarge scale;
2: With thionyl chloride in methanol
T=10 - 25°C; 3.5 h; Inert atmosphereLarge scale;
3: tert-butyl methyl ether T=-5 - 30°C; 1.45 h; Large scale; TemperatureTimeReagent/catalyst;
参考文献
Betti, Matteo; Genesio, Eva; Panico, Alessandro; Sanna Coccone, Salvatore; Wiedenau, Paul
Organic Process Research and Development, 2013 , vol. 17, # 8 p. 1042 - 1051
反应条件
chloro-trimethyl-silane
T=20°C; 12 h;
参考文献
Li, Jiabo; Sha, Yaowu
Molecules, 2008 , vol. 13, # 5 p. 1111 - 1119
参考文献
Einhorn; Ladisch
Justus Liebigs Annalen der Chemie, 1900 , vol. 310, p. 194
