1-(2-甲氧基苯基)哌嗪盐酸盐合成路线 （共 16 条）
反应条件
hydrogenchloride in diethyl ether
参考文献
AGIOS PHARMACEUTICALS, INC.; SALITURO, Francesco, G.; SAUNDERS, Jeffrey, O.
Patent: WO2011/72174 A1, 2011 ;
Location in patent: Page/Page column 100 ;
WO 2011/072174 A1
反应条件
1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 100 °C / Inert atmosphere 2: hydrogenchloride / diethyl ether / 2 h View Scheme
参考文献
WO2011/72174 A1, ;
WO 2011/072174 A1
反应条件
1: 1-(2-methoxyphenyl)piperazine monohydrochloride With sodium carbonate; β-cyclodextrin in water T=25°C; 2: 6-[(3-chloropropyl)amino]-1,3-dimethyluracil in water T=95°C; Kinetics; ConcentrationTemperature;
参考文献
Li, Wen; Zhang, Wenya; Ma, Xiaoqing; Wang, Panpan; Du, Menghong
Applied Catalysis A: General, 2012 , vol. 419-420, p. 210 - 214
反应条件
1: 75 percent / K2CO3 / acetonitrile / 14 h / Heating 2: 93 percent / hydrazine hydrate / methanol / 2 h / Heating View Scheme
参考文献
Hackling, Anneke; Ghosh, Robin; Perachon, Sylvie; Mann, Andre; Hoeltje, Hans-Dieter; Wermuth, Camille G.; Schwartz, Jean-Charles; Sippl, Wolfgang; Sokoloff, Pierre; Stark, Holger
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3883 - 3899
反应条件
triethylamine in dichloromethane T=0°C; 0.5 h; Inert atmosphere;
参考文献
Biswas, Swati; Hazeldine, Stuart; Ghosh, Balaram; Parrington, Ingrid; Kuzhikandathil, Eldo; Reith, Maarten E. A.; Dutta, Aloke K.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 10 p. 3005 - 3019
反应条件
in 1-chloro-3-[4-(2-methoxyphenyl)-piperazin-1-yl]propane
参考文献
HELTON, David; FICK, David
Patent: US2009/264443 A1, 2009 ;
反应条件
sodium hydroxide in water 0.166667 h;
参考文献
BAYLOR UNIVERSITY
Patent: WO2005/94896 A2, 2005 ;
Location in patent: Page/Page column 21 ;
WO 2005/094896 A2
反应条件
potassium carbonate; potassium iodide in DMF (N,N-dimethyl-formamide) T=75 - 80°C; 18 h;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2005/21521 A1, 2005 ;
Location in patent: Page/Page column 9-10 ;
WO 2005/021521 A1
反应条件
1: With sodium tris(acetoxy)borohydride; acetic acid in dichloromethane T=20°C; 0.333333 h; 2: With hydrogen bromide
参考文献
Kowalski, Piotr; Jaskowska, Jolanta
Archiv der Pharmazie, 2012 , vol. 345, # 1 p. 81 - 85
反应条件
hydrogenchloride; sodium hydroxide; potassium carbonate in tetrahydrofuran; water
参考文献
Syntex (U.S.A.) Inc.
Patent: US5688795 A1, 1997 ;
