3-氨基-5-氯-6-甲基-2-吡嗪甲腈合成路线 （共 3 条）
反应条件
1: 1.) CH3ONa / 1.) methanol; 2.) reflux, 20 h. 2: 82 percent / 2percent aq. NaOH / 0.08 h / Heating View Scheme
参考文献
Neilsen; Broadbent; Hennen
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 6 p. 1621 - 1628
反应条件
trichlorophosphate in N,N-dimethyl-formamide
T=0 - 80°C; 2 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/117050 A1, 2008 ;
Location in patent: Page/Page column 71-72 ;
WO 2008/117050 A1
反应条件
1: 1.) CH3ONa / 1.) methanol; 2.) reflux, 20 h.
2: 82 percent / 2percent aq. NaOH / 0.08 h / Heating
3: 96 percent / 10percent hydrochloric acid / 28 h / Heating
View Scheme
参考文献
Neilsen; Broadbent; Hennen
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 6 p. 1621 - 1628
