N-(3-溴丙基)苯二胺合成路线 （共 93 条）
反应条件
1: With sodium hydride in N,N-dimethyl-formamide
T=25 - 70°C;
2: With hydrazine in ethanol
12 h; Heating / reflux;
参考文献
SCHERING CORPORATION
Patent: WO2007/84498 A1, 2007 ;
Location in patent: Page/Page column 186 ;
反应条件
[Ni0(1,5-cyclooctadiene)2]; zinc; (4-Cl)-H-PyBox in N,N-dimethyl acetamide
T=25°C; 16 h; Inert atmosphere;
参考文献
Yu, Xiaolong; Yang, Tao; Wang, Shulin; Xu, Hailiang; Gong, Hegui
Organic Letters, 2011 , vol. 13, # 8 p. 2138 - 2141
反应条件
1: 92 percent / dimethylsulfoxide / 25 °C
2: 95 percent / aq. sodium periodate / methanol / 25 °C
View Scheme
参考文献
Sato, Yasuhiko; Nakai, Hideo; Wada, Masao; Mizoguchi, Tomishige; Hatanaka, Yasumaru; et al.
Liebigs Annalen der Chemie, 1985 , # 6 p. 1099 - 1118
反应条件
sodium hydrogencarbonate; triethylamine in isopropyl alcohol
参考文献
Mitsubishi Gas Chemical Co., Inc.
Patent: US5244487 A1, 1993 ;
参考文献
Clinch, Keith; Crump, Douglas R.; Evans, Gary B.; Hazleton, Keith Z.; Mason, Jennifer M.; Schramm, Vern L.; Tyler, Peter C.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5629 - 5646
反应条件
(i) xylene, (ii) N2H4*H2O; Multistep reaction;
参考文献
Ueda,T.; Ishizaki,K.
Chemical and Pharmaceutical Bulletin, 1967 , vol. 15, p. 228 - 232
参考文献
Dreher, Michael; Elias, Horst; Paulus, Helmut
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 6 p. 707 - 710
反应条件
sodium iodide in acetone
14 h; Heating;
参考文献
Zhou, Jianrong; Fu, Gregory C.
Journal of the American Chemical Society, 2003 , vol. 125, # 41 p. 12527 - 12530
反应条件
1: 88 percent / dimethylsulfoxide / 2 h / 65 °C
2: 54.5 percent / H2, HCl conc. / PtO2 / ethanol / 24 h / 2327.2 Torr
3: 87.6 percent / Et3N / CH2Cl2 / 4 h
4: 96 percent / NaNO2 / acetic acid; acetic anhydride / 4 °C
5: 54 percent / Na2CO3 / CCl4 / 40 h / Heating
6: 90.4 percent / NaI / acetone / 2 h / Heating
View Scheme
参考文献
Thiruvengadam; Gould; Aberhart; Horng Jau Lin
Journal of the American Chemical Society, 1983 , vol. 105, # 16 p. 5470 - 5476
反应条件
(i) Na, EtOH, (ii) N2H4*H2O; Multistep reaction;
参考文献
Amundsen; Whelan; Bosnich
Journal of the American Chemical Society, 1977 , vol. 99, # 20 p. 6730 - 6739
