N-(3-溴丙基)苯二胺合成路线 （共 93 条）
反应条件
in anhydrous xylene
T=70°C; Reflux;
参考文献
Ovat, Asli; Li, Zhao Zhao; Hampton, Christina Y.; Asress, Seneshaw A.; Fernandez, Facundo M.; Glass, Jonathan D.; Powers, James C.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 17 p. 6326 - 6336
反应条件
1: acetonitrile / 0.25 h / 200 °C / |Microwave irradiation
2: sodium methylate / N,N-dimethyl-formamide / 0.25 h / 200 °C / |Microwave irradiation
3: hydrogen; palladium on activated charcoal / tetrahydrofuran; methanol / 0.83 h
View Scheme
参考文献
Harusawa, Shinya; Sawada, Koichi; Magata, Takuji; Yoneyama, Hiroki; Araki, Lisa; Usami, Yoshihide; Hatano, Kouta; Yamamoto, Kouichi; Yamamoto, Daisuke; Yamatodani, Atsushi
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 23 p. 6415 - 6420
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
Shan, Wen-Jun; Huang, Ling; Zhou, Qi; Meng, Fan-Chao; Li, Xing-Shu
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 5885 - 5893
反应条件
in acetonitrile
T=80°C; 12 h; Sealed tube;
参考文献
Pan, Xiangcheng; Curran, Dennis P.
Organic Letters, 2014 , vol. 16, # 10 p. 2728 - 2731
反应条件
potassium carbonate in acetone
Heating;
参考文献
Boschelli, Diane H.; Connor, David T.; Lesch, Mark E.; Schrier, Denis J.
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 4 p. 557 - 562
反应条件
in ethanol
Substitution; 2 h; Heating;
参考文献
El-Bardan, Ali A.
Phosphorus, Sulfur and Silicon and Related Elements, 1998 , vol. 134-135, p. 511 - 519
反应条件
sodium methylate in methanol
Yield given;
参考文献
McCormick, Joan E.; McElhinney, R. Stanley
Journal of Chemical Research, Miniprint, 1983 , # 7 p. 1736 - 1800
反应条件
in ethanol
Substitution; 2 h; Heating;
参考文献
El-Bardan, Ali A.
Phosphorus, Sulfur and Silicon and Related Elements, 1998 , vol. 134-135, p. 511 - 519
反应条件
sodium azide; adogen 464 in water; benzene
参考文献
Eguchi, Shoji; Takeuchi, Hisato
Journal of the Chemical Society, Chemical Communications, 1989 , # 9 p. 602 - 603
反应条件
potassium iodide; potassium carbonate in acetonitrile
参考文献
Fujirebio Kabushiki Kaisha
Patent: US4988828 A1, 1991 ;
US 4988828 A
