3,5-二甲基-4-异恶唑甲醛合成路线 （共 12 条）
反应条件
barium permanganate in benzene 3 h; Heating;
参考文献
Mirzaei; Bavili-Tabrizi; Hashemi-Gohare; Zare-Neirizi; Edjlali
Organic Preparations and Procedures International, 2003 , vol. 35, # 2 p. 207 - 214
反应条件
N-bromosuccinmide in water; acetonitrile T=-5 - 30°C; 0.166667 h;
参考文献
Mellor, John M.; Schofield, Stephen R.; Korn, Stewart R.
Tetrahedron, 1997 , vol. 53, # 50 p. 17151 - 17162
反应条件
1: 68 percent / lithium aluminum hydride / tetrahydrofuran / 1.) 0 deg C, 2.) room temperature 2: 53 percent / potassium dichromate, Adogen-464 / ethyl acetate / 18 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 13, # 10 p. 817 - 822
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 2: Dess-Martin periodane / dichloromethane / 1.17 h / 0 - 20 °C View Scheme
参考文献
WO2013/19635 A1, ;
WO 2013/019635 A1
反应条件
1: 99 percent / NH2OH*HCl / ethanol / 2 h / Heating 2: 78 percent / NBS / H2O; acetonitrile / 0.17 h / -5 - 30 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 50 p. 17151 - 17162
反应条件
1: 74 percent / K2CO3 / dimethylformamide / 7 h 2: 92 percent / Mg / methanol / 24 h / 5 °C 3: 99 percent / NH2OH*HCl / ethanol / 2 h / Heating 4: 78 percent / NBS / H2O; acetonitrile / 0.17 h / -5 - 30 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 50 p. 17151 - 17162
反应条件
1: 92 percent / Mg / methanol / 24 h / 5 °C 2: 99 percent / NH2OH*HCl / ethanol / 2 h / Heating 3: 78 percent / NBS / H2O; acetonitrile / 0.17 h / -5 - 30 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 50 p. 17151 - 17162
反应条件
1: sulfuric acid / water / 0 - 70 °C 2: manganese(IV) oxide / ethyl acetate / 72 h / 20 °C View Scheme
参考文献
EP1186604 A1, ;
EP 1186604 A1
反应条件
1: tetrahydrofuran; diethyl ether / 1.67 h / 0 - 20 °C 2: pyridinium chlorochromate / dichloromethane / 1 h / 0 - 20 °C View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
WO 2013/019682 A1
反应条件
methanol; sodium tetrahydroborate T=0 - 20°C;
参考文献
CHLORION PHARMA, INC.; UNIVERSITE LAVAL; ATTARDO, Giorgio; TRIPATHY, Sasmita
Patent: WO2010/132999 A1, 2010 ;
Location in patent: Page/Page column 109 ;
