反应条件
1: 4-(N,N-dimethlyamino)pyridine; diisopropyl-carbodiimide / dichloromethane / 72 h / 20 °C
2: toluene-4-sulfonic acid / benzene / 3 h / |Dean-Stark; |Reflux
3: lithium aluminium tetrahydride / diethyl ether / 3 h / 20 °C / |Inert atmosphere; |Reflux
View Scheme
参考文献
ACHAOGEN, INC.; PATTERSON, Brian, D.; LU, Qing; AGGEN, James, Bradley; DOZZO, Paola; KASAR, Ramesh, Annasaheb; LINSELL, Martin, Sheringham; KANE, Timothy, Robert; GLIEDT, Micah, James; HILDEBRANDT, Darin, James; MCENROE, Glenn, A.; COHEN, Frederick
Patent: WO2013/170030 A1, 2013 ;