3-氰基-4,6-二甲基-2-硫基吡啶合成路线 （共 31 条）
反应条件
sodium ethanolate in ethanol
1.5 h; Heating;
参考文献
Wagner; Vieweg; Leistner; Bohm; Krasselt; Hanfe ld; Prantz; Grupe
Pharmazie, 1990 , vol. 45, # 2 p. 102 - 109
反应条件
1.1: 89 percent / aq. KOH / dimethylformamide / 20 °C
2.1: H2SO4; aq. NaNO2; glacial acetic acid / 5 - 7 °C
2.2: 78 percent / aq. NaN3
View Scheme
参考文献
Vasilin; Kaigorodova; Firgang; Krapivin
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 3 p. 377 - 386
反应条件
1: 7.5 g / KOH / ethanol; H2O / 0.25 h
2: 50 percent / conc. H2SO4 (d=1.83) / 1 h / 100 °C
3: 67 percent / KOH / ethanol; H2O / 10 h / Ambient temperature
View Scheme
参考文献
Zawisza; Malinka
Farmaco, Edizione Scientifica, 1985 , vol. 40, # 2 p. 124 - 132
反应条件
1: KOH
2: aq. KOH
3: aq. HCl
View Scheme
参考文献
Guerrera; Siracusa; Tornetta
Farmaco, Edizione Scientifica, 1976 , vol. 31, # 1 p. 21 - 30
反应条件
1.1: aq. KOH / dimethylformamide / 0.17 h / 20 °C
1.2: 72 percent / dimethylformamide / 0.08 h / 20 °C
2.1: 87 percent / MeONa / methanol / 0.25 h / Heating
3.1: 70 percent / hydrochloric acid / 2 h / Heating
View Scheme
参考文献
Fedorov; Shestopalov; Belyakov
Russian Chemical Bulletin, 2003 , vol. 52, # 9 p. 2063 - 2069
反应条件
potassium hydroxide in N,N-dimethyl-formamide
参考文献
Youssef; Ibrahim; Attia, Hanaa A.E.; Hamouda
Egyptian Journal of Chemistry, 2008 , vol. 51, # 2 p. 163 - 175
反应条件
1: With sulfuric acid
T=100°C; 4 h;
2: With sodium hydrogencarbonate in water
pH=5 - 6;
参考文献
CHANG, Zee-Fen; HU, Chun-Mei; FANG, Jim-Min; YEH, Ming-Tyng
Patent: WO2012/72019 A1, 2012 ;
Location in patent: Page/Page column 64 ;
WO 2012/072019 A1
反应条件
potassium hydroxide in water; N,N-dimethyl-formamide
T=20 - 50°C; 0.75 h;
参考文献
VANDERBILT UNIVERSITY; CONN, P., Jeffrey; LINDSLEY, Craig, W.; WOOD, Michael, R.; HOPKINS, Corey, R.; SALOVICH, James, M.; MELANCON, Bruce, J.
Patent: WO2013/40534 A1, 2013 ;
Location in patent: Paragraph 00690 ;
反应条件
1: 84 percent / sodium acetate / ethanol / 0.5 h / Heating
2: 92 percent / NaOC2H5 / ethanol / 0.25 h / Heating
View Scheme
参考文献
Hassan, Kh. M.; El-Dean, A. M. Kamal; Youssef, M. S. K.; Atta, F. M.; Abbady, M. S.
Phosphorus, Sulfur and Silicon and the Related Elements, 1990 , vol. 47, # 1 + 2 p. 181 - 189
反应条件
potassium hydroxide in N,N-dimethyl-formamide
T=20°C;
参考文献
Vasilin; Kaigorodova; Firgang; Krapivin
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 3 p. 377 - 386
