2-甲基-6-羟基苯并呋喃合成路线 （共 9 条）
反应条件
boron tribromide in dichloromethane
T=-5 - 0°C; 1.5 h;
参考文献
PFIZER INC.
Patent: WO2005/63739 A1, 2005 ;
Location in patent: Page/Page column 129 ;
WO 2005/063739 A1
反应条件
1: With sodium tetrahydroborate in ethanol
T=20°C;
2: With hydrogenchloride in ethanol; water
T=20°C;
参考文献
Ge, Min; He, Jiafang; Lau, Fiona Wai Yu; Liang, Gui-Bai; Lin, Songnian; Liu, Weiguo; Walsh, Shawn P.; Yang, Lihu
Patent: US2007/265332 A1, 2007 ;
Location in patent: Page/Page column 22-23 ;
US 20070265332 A1
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US2004/9965 A1, 2004 ;
反应条件
sodium carbonate; p-benozquinone; dichloro bis(acetonitrile) palladium(II) in 1,4-dioxane
T=65°C; 5 h; Title compound not separated from byproducts;
参考文献
So, Won Youn; Jeong, Im Eom
Organic Letters, 2005 , vol. 7, # 15 p. 3355 - 3358
反应条件
1: K2CO3 / dimethylformamide / 0 - 20 °C
2: 1,4-benzoquinone; Na2CO3 / Pd(MeCN)2Cl2 / dioxane / 5 h / 65 °C
View Scheme
参考文献
So, Won Youn; Jeong, Im Eom
Organic Letters, 2005 , vol. 7, # 15 p. 3355 - 3358
反应条件
boron tribromide in dichloromethane
T=20°C; Cyclization; demethylation; 1 h;
参考文献
Dupont, Romain; Cotelle, Philippe
Synthesis, 1999 , # 9 p. 1651 - 1655
反应条件
toluene dioxygenase from Pseudomonas putida UV4
Enzymatic reaction; optical yield given as percent ee;
参考文献
Boyd, Derek R.; Sharma, Narain D.; Brannigan, Ian N.; Evans, Timothy A.; Haughey, Simon A.; McMurray, Brian T.; Malone, John F.; McIntyre, Peter B. A.; Stevenson, Paul J.; Allen, Christopher C. R.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 36 p. 7292 - 7304
反应条件
triethylamine in dichloromethane
T=0°C; 16 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/92751 A2, 2007 ;
Location in patent: Page/Page column 27 ;
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US2004/9965 A1, 2004 ;
