2-(3-碘丙基)-1H-异吲哚-1,3(2H)-二酮合成路线 （共 22 条）
反应条件
triethylamine in 2-ethoxy-ethanol T=110°C; 2 h;
参考文献
KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
Patent: WO2007/127930 A2, 2007 ;
Location in patent: Page/Page column 13; 19 ;
反应条件
1: ethyl acetoacetate With potassium carbonate in acetone 1 h; Reflux; 2: 2-(3-iodopropyl)-1H-isoindolone-1,3(2H)-dione in acetone 255 h; Reflux;
参考文献
Prabhakar; Kumar, N. Vasanth; Reddy, M. Ravikanth; Sarma; Reddy, G. Om
Organic Process Research and Development, 1999 , vol. 3, # 3 p. 155 - 160
反应条件
sodium iodide in acetone
14 h; Heating;
参考文献
Zhou, Jianrong; Fu, Gregory C.
Journal of the American Chemical Society, 2003 , vol. 125, # 41 p. 12527 - 12530
反应条件
1: H2, conc. HCl / PtO2 / ethanol / 760 Torr
2: Et3N / CH2Cl2 / 24 h / Ambient temperature
3: 87 percent / Ac2O, sodium nitrite / acetic acid / 10 h / 0 °C
4: 0.78 g / Na2CO3 / CCl4 / 24 h / Heating
5: NaI / acetone / 20 h / Heating
View Scheme
参考文献
Prabhakaran; Woo; Yorgey; Gould
Journal of the American Chemical Society, 1988 , vol. 110, # 17 p. 5785 - 5791
反应条件
1: 84 percent / dimethylsulfoxide / 6 h / 65 °C
2: H2, conc. HCl / PtO2 / ethanol / 760 Torr
3: Et3N / CH2Cl2 / 24 h / Ambient temperature
4: 87 percent / Ac2O, sodium nitrite / acetic acid / 10 h / 0 °C
5: 0.78 g / Na2CO3 / CCl4 / 24 h / Heating
6: NaI / acetone / 20 h / Heating
View Scheme
参考文献
Prabhakaran; Woo; Yorgey; Gould
Journal of the American Chemical Society, 1988 , vol. 110, # 17 p. 5785 - 5791
反应条件
sodium iodide in acetone
2 h; Heating;
参考文献
Martinkus; Tann; Gould
Tetrahedron, 1983 , vol. 39, # 21 p. 3493 - 3505
反应条件
1H-imidazole; iodine; triphenylphosphine in dichloromethane
4 h; Inert atmosphereSchlenk technique;
参考文献
Levin, Vitalij V.; Zemtsov, Artem A.; Struchkova, Marina I.; Dilman, Alexander D.
Organic Letters, 2013 , vol. 15, # 4 p. 917 - 919
反应条件
sodium iodide in acetone
12 h; Reflux;
参考文献
Prabhakar; Kumar, N. Vasanth; Reddy, M. Ravikanth; Sarma; Reddy, G. Om
Organic Process Research and Development, 1999 , vol. 3, # 3 p. 155 - 160
反应条件
1: 87 percent / Ac2O, sodium nitrite / acetic acid / 10 h / 0 °C
2: 0.78 g / Na2CO3 / CCl4 / 24 h / Heating
3: NaI / acetone / 20 h / Heating
View Scheme
参考文献
Prabhakaran; Woo; Yorgey; Gould
Journal of the American Chemical Society, 1988 , vol. 110, # 17 p. 5785 - 5791
反应条件
1: Et3N / CH2Cl2 / 24 h / Ambient temperature
2: 87 percent / Ac2O, sodium nitrite / acetic acid / 10 h / 0 °C
3: 0.78 g / Na2CO3 / CCl4 / 24 h / Heating
4: NaI / acetone / 20 h / Heating
View Scheme
参考文献
Prabhakaran; Woo; Yorgey; Gould
Journal of the American Chemical Society, 1988 , vol. 110, # 17 p. 5785 - 5791
