6-(3-硝基苯基)吡嗪-3(2H)-酮合成路线 （共 8 条）
反应条件
palladium in hydrogen; trifluoroacetic acid
参考文献
American Cyanamid Company
Patent: US4654343 A1, 1987 ;
反应条件
hydrazine in butan-1-ol
Heating / reflux;
参考文献
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Patent: WO2008/30744 A2, 2008 ;
Location in patent: Page/Page column 54 ;
WO 2008/030744 A2
反应条件
bromine in acetic acid
参考文献
American Cyanamid Company
Patent: US4112095 A1, 1978 ;
反应条件
bromine; acetic acid
1 h; Heating;
参考文献
Albright, J. D.; Moran, D. B.; Wright, W. B.; Collins, J. B.; Beer, B.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 592 - 600
反应条件
1: Hydrazine hydrochloride, KOH / H2O / 2 h / Heating
2: bromine / acetic acid / 1 h / Heating
View Scheme
参考文献
Shkurko, O. P.; Kuznetsov, S. A.; Denisov, A. Yu.; Mamaev, V. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1986 , vol. 22, # 7 p. 763 - 770
Khimiya Geterotsiklicheskikh Soedinenii, 1986 , vol. 22, # 7 p. 951 - 958
反应条件
ammonium hydroxide; hydrazine hydrate
1) heating, 2) water, reflux; Yield given. Multistep reaction;
参考文献
Coates; McKillop
Synthesis, 1993 , # 3 p. 334 - 342
反应条件
1: 45 percent / POCl3 / Heating
2: 73 percent / butan-1-ol / 48 h / Heating
3: 92 percent / H2 / 10percent Pd/C / trifluoroacetic acid / 1.5 h
View Scheme
参考文献
Albright, J. D.; Moran, D. B.; Wright, W. B.; Collins, J. B.; Beer, B.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 592 - 600
反应条件
trichlorophosphate
1 h; Heating / reflux;
参考文献
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Patent: WO2008/30744 A2, 2008 ;
Location in patent: Page/Page column 54-55 ;
WO 2008/030744 A2
