2-苯基氨基亚甲基-丙二酸二乙酯合成路线 （共 32 条）
反应条件
1.1: 77 percent / diphenyl ether / 4 h / Heating 2.1: NaH / dimethylformamide / 20 °C 2.2: 75 percent / dimethylformamide / 6 h / 90 °C 3.1: 75 percent / aq. NaOH / ethanol / 3 h / Heating View Scheme
参考文献
Stern, Eric; Muccioli, Giulio G.; Millet, Regis; Goossens, Jean-Francois; Farce, Amaury; Chavatte, Philippe; Poupaert, Jacques H.; Lambert, Didier M.; Depreux, Patrick; Henichart, Jean-Pierre
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 70 - 79
反应条件
1: diphenyl ether / Heating 2: 95 percent / aq. KOH / Heating View Scheme
参考文献
Chemical Communications, , # 43 p. 5438 - 5440
反应条件
1: PPA; trichlorophosphate 2: sodium hydroxide View Scheme
反应条件
1: 1.26 g / diphenyl ether / 1 h / 250 °C 2: 95 percent / thionyl chloride; DMF / 1 h / 80 °C View Scheme
参考文献
Li, Xiangqian; Wang, Ziqian; Feng, Yingang; Song, Ting; Su, Pengchen; Chen, Chengbin; Chai, Gaobo; Yang, Ying; Zhang, Zhichao
ChemBioChem, 2014 , vol. 15, # 9 p. 1280 - 1285
反应条件
bromine; acetic acid
参考文献
Upadhyaya; Desai
Journal of the Indian Chemical Society, 1957 , vol. 34, p. 817,819
参考文献
Upadhyaya; Desai
Journal of the Indian Chemical Society, 1957 , vol. 34, p. 817,819
反应条件
in o-dibenzylbenzene
参考文献
Dynamit Nobel AG
Patent: US4079058 A1, 1978 ;
反应条件
PPA; trichlorophosphate
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
Erhitzen auf Siedetemperatur;
参考文献
Riegel et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 1264
反应条件
1: With sodium hydride in tetrahydrofuran
T=20°C; 12 h;
2: With methanol in tetrahydrofuran
参考文献
Brion, Jean-Daniel; Israel, Lucien; Le Ridant, Alain; Harpey, Catherine; Rabhi, Cherif; Kaloun, El Bachir
Patent: US2006/63801 A1, 2006 ;
Location in patent: Page/Page column 7 ;
