吡啶-2.6-二羧酸二甲酯合成路线 （共 63 条）
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: US5234946 A1, 1993 ;
反应条件
1: 39 percent / NaBH4 / methanol; H2O / 4 h / 20 °C 2: 90 percent / aq. NaOH / methanol / 0.17 h / 100 °C / microwave irradiation View Scheme
参考文献
Wang, Shuai; Cuesta-Seijo, Jose A.; Lafont, Dominique; Palcic, Monica M.; Vidal, Sebastien
Chemistry - A European Journal, 2013 , vol. 19, # 45 p. 15346 - 15357
反应条件
potassium hydroxide in methanol T=0 - 20°C; 26 h;
参考文献
Yang, Zhengfa; Tang, Ruiren; Zhang, Zhenfeng
Journal of Molecular Structure, 2012 , vol. 1030, p. 19 - 25
反应条件
1: NaBH4 / methanol 2: thionyl chloride / benzene View Scheme
参考文献
Kimura, Eiichi; Machida, Ryosuke; Kodama, Mutsuo
Journal of the American Chemical Society, 1984 , vol. 106, # 19 p. 5497 - 5505
反应条件
sodium hydroxide; phosphate buffer 13 h; Ambient temperaturepig liver esterase;
参考文献
Ager; Prakash
Synthetic Communications, 1995 , vol. 25, # 5 p. 739 - 742
反应条件
1: sodium tetrahydroborate / ethanol / 13 h / 0 - 20 °C / |Reflux 2: hydrogen bromide / 15 h / |Reflux View Scheme
参考文献
Yu, Kang-Kang; Li, Kun; Hou, Ji-Ting; Yu, Xiao-Qi
Tetrahedron Letters, 2013 , vol. 54, # 43 p. 5771 - 5774
反应条件
diisobutylaluminium hydride in dichloromethane T=-78°C; 3 h;
参考文献
Masiero, Stefano; Fini, Federico; Gottarelli, Giovanni; Spada, Gian Piero
Journal of Chemical Research, Miniprint, 1998 , # 10 p. 2736 - 2753
反应条件
1: With hydroxylamine in methanol; chloroform T=20°C; 18 h; 2: With hydrogenchloride pH=3; Further stages.;
参考文献
Swiatek-Kozlowska, Jolanta; Gumienna-Kontecka, Elzbieta; Dobosz, Agnieszka; Golenya, Irina A.; Fritsky, Igor O.
Journal of the Chemical Society. Dalton Transactions, 2002 , # 24 p. 4639 - 4643
反应条件
1: sodium hydroxide / water / 12 h / 20 °C 2: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / -10 - -5 °C 3: sodium azide / tetrahydrofuran; water; N,N-dimethyl-formamide / 0.5 h / Cooling 4: toluene / 30 h / 120 °C 5: palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 3 h / 50 °C View Scheme
参考文献
Zhao, Huaiqing; Ong, Wei Qiang; Fang, Xiao; Zhou, Feng; Hii, Meng Ni; Li, Sam Fong Yau; Su, Haibin; Zeng, Huaqiang
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 6 p. 1172 - 1180
反应条件
1: 16 h / 120 °C 2: tosyl chloride; triethylamine / CH2Cl2 / 20 h / Heating View Scheme
参考文献
Joensson, Christina; Lundgren, Stina; Haswell, Stephen J.; Moberg, Christina
Tetrahedron, 2004 , vol. 60, # 46 SPEC. ISS. p. 10515 - 10520
