吡啶-2.6-二羧酸二甲酯合成路线 （共 63 条）
反应条件
thionyl chloride 3 h; Heating;
参考文献
CHONG KUN DANG PHARMACEUTICAL CORP.
Patent: WO2004/37808 A1, 2004 ;
Location in patent: Page 9-10 ;
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran 4 h; Reflux;
参考文献
Tetrahedron, , vol. 67, # 44 p. 8458 - 8464
反应条件
triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride T=140°C; methoxycarbonylation; P=37503 Torr; 6 h;
参考文献
Najiba, Douja; Carpentier, Jean-Francois; Castanet, Yves; Biot, Christophe; Brocard, Jacques; Mortreux, Andre
Tetrahedron Letters, 1999 , vol. 40, # 19 p. 3719 - 3722
反应条件
1: pyridine-2,6-dicarboxylic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile 0.166667 h; 2: methyl iodide in acetonitrile T=20°C; 4 h;
参考文献
Mal, Dipakranjan; Jana, Amit; Ray, Sutapa; Bhattacharya, Sourav; Patra, Asit; De, Saroj R.
Synthetic Communications, 2008 , vol. 38, # 22 p. 3937 - 3946
反应条件
methanol; thionyl chloride 16 h; Reflux;
参考文献
Dungan, Victoria J.; Poon, Belinda M.-L.; Barrett, Elizabeth S.; Rutledge, Peter J.
Tetrahedron Letters, 2013 , vol. 54, # 10 p. 1236 - 1238
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; sodium acetate; palladium diacetate T=135°C; Carboxylation; P=11250.9 Torr; 1 h;
参考文献
Bessard, Yves; Crettaz, Roger
Heterocycles, 1999 , vol. 51, # 11 p. 2589 - 2602
反应条件
sulfuric acid in water 1) 15 min, reflux, 2) RT, 10 h;
参考文献
Journal of Organic Chemistry, , vol. 46, # 24 p. 4914 - 4920
参考文献
Jahresbericht ueber die Fortschritte der Chemie und Verwandter Theile Anderer Wissenschaften, , p. 436
参考文献
Australian Journal of Chemistry, , vol. 38, # 10 p. 1491 - 1497
反应条件
1: potassium permanganate 2: phosphorus pentachloride View Scheme
参考文献
Jahresbericht ueber die Fortschritte der Chemie und Verwandter Theile Anderer Wissenschaften, , p. 436
