2-氧代环辛烷-1-羧酸甲酯合成路线 （共 14 条）
反应条件
sodium hydroxide; water anschl. mit wss. HCl;
参考文献
Blicke et al.
Journal of the American Chemical Society, 1953 , vol. 75, p. 5418
反应条件
1: carbonic acid dimethyl ester With sodium hydride in tetrahydrofuran
T=5 - 10°C; 0.5 h; Inert atmosphere;
2: cyclo-octatrienone in tetrahydrofuran
4.5 h; RefluxInert atmosphere;
参考文献
BEIGENE, LTD.; ZHOU, Changyou; REN, Bo; WANG, Hexiang
Patent: WO2013/97226 A1, 2013 ;
Location in patent: Page/Page column 40 ;
反应条件
lithium perchlorate; triethylamine in acetonitrile
3 h; Irradiation; Yields of byproduct given;
参考文献
Cossy, Janine; Furet, Nathalie
Tetrahedron Letters, 1993 , vol. 34, # 50 p. 8107 - 8110
反应条件
lithium perchlorate; triethylamine in acetonitrile
5 h; Irradiation; Yields of byproduct given;
参考文献
Cossy, Janine; Furet, Nathalie; BouzBouz, Samir
Tetrahedron, 1995 , vol. 51, # 43 p. 11751 - 11764
反应条件
n-butyllithium; diisopropylamine
1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, from -78 deg C to 25 deg C, 3 h; Multistep reaction;
参考文献
Winkler, Jeffrey D.; Hong, Bor-Cherng; Hey, John P.; Williard, Paul G.
Journal of the American Chemical Society, 1991 , vol. 113, # 23 p. 8839 - 8846
反应条件
1: 50 percent / sodium hydride / dimethylsulfoxide / r. t., 2 h, 50 degC, 1 h
2: 80 percent / triethylamine, lithium perchlorate / acetonitrile / 5 h / Irradiation
View Scheme
参考文献
Cossy, Janine; Furet, Nathalie; BouzBouz, Samir
Tetrahedron, 1995 , vol. 51, # 43 p. 11751 - 11764
反应条件
metastable ion fragmentation reaction of selected ions;
参考文献
Harrison, Alex. G.; Kallury, R. Krishna Mohan Rao; Krull, Ulrich J.; Thompson, Michael
Organic Mass Spectrometry, 1988 , vol. 23, p. 723 - 728
反应条件
methanol; sodium
Heating;
参考文献
Sum,P.-E.; Weiler,L.
Canadian Journal of Chemistry, 1977 , vol. 55, p. 996 - 1000
反应条件
1: (i) NaH, THF, (ii) nBuLi, hexane, (iii) /BRN= 1209245/
2: Na, MeOH / Heating
View Scheme
参考文献
Sum,P.-E.; Weiler,L.
Canadian Journal of Chemistry, 1977 , vol. 55, p. 996 - 1000
反应条件
1: (i) NaH, THF, (ii) nBuLi, hexane, (iii) /BRN= 1209245/
2: Na, MeOH / Heating
View Scheme
参考文献
Sum,P.-E.; Weiler,L.
Canadian Journal of Chemistry, 1977 , vol. 55, p. 996 - 1000
