2-(1-苯基亚乙基)丙二腈合成路线 （共 27 条）
反应条件
1: (S)-2-(4-methoxy-phenyl)-butylmagnesium chloride / diethyl ether / 18 h / Ambient temperature 2: (i) KOH, H2O, (ii) (heating), (iii) /BRN= 102415/, Et2O View Scheme
参考文献
Cabaret,D. et al.
Journal of Organometallic Chemistry, 1976 , vol. 113, p. 215 - 224
反应条件
triethylamine in N,N-dimethyl-formamide 0.666667 h; Ambient temperature;
参考文献
Gewald, Karl; Hain, Ute
Zeitschrift fuer Chemie (Stuttgart, Germany), 1986 , vol. 26, # 12 p. 434 - 435
反应条件
copper(II) bis(trifluoromethanesulfonate); triethylamine in acetonitrile
5 h; Reflux;
参考文献
Su, Weike; Ding, Kai; Chen, Zhiwei
Tetrahedron Letters, 2009 , vol. 50, # 6 p. 636 - 639
反应条件
[BmIm]OH; air in ethanol
4 h; Reflux;
参考文献
Babu, G. Neelaiah; Ayalew, Haile Micheal; Jain, Shubha
Medicinal Chemistry Research, 2014 , vol. 23, # 5 p. 2608 - 2614
反应条件
triethylamine in N,N-dimethyl-formamide
0.666667 h; Ambient temperature;
参考文献
Gewald, Karl; Hain, Ute
Zeitschrift fuer Chemie (Stuttgart, Germany), 1986 , vol. 26, # 12 p. 434 - 435
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 0.5 h;
参考文献
Peseke, Klaus; Suarez, Jose Quincoces
Zeitschrift fuer Chemie (Stuttgart, Germany), 1983 , vol. 23, # 11 p. 404 - 405
反应条件
piperidine in diethyl ether
1.25 h; Ambient temperature;
参考文献
Abramenko, Yu. T.; Ivashchenko, A. V.; Nogaeva, K. A.; Andronova, N. A.; Putsykina, E. B.
Journal of Organic Chemistry USSR (English Translation), 1986 , vol. 22, p. 230 - 235
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 2 p. 264 - 269
反应条件
1H-imidazole in tetrahydrofuran
T=20°C; 24 h;
参考文献
Liu, Xu-Guang; Shi, Min
European Journal of Organic Chemistry, 2008 , # 36 p. 6168 - 6174
反应条件
piperidine in ethanol
120 h; Ambient temperature;
参考文献
Martin-Leon, Nazario; Segura, Jose L.; Seoane, Carlos; Soto, Jose L.
Journal of Chemical Research, Miniprint, 1990 , # 10 p. 2434 - 2452
反应条件
1: 80 percent / S; Et3N / ethanol / 3 h / Heating
2: 70 percent / Et3N / ethanol / 2 h / Heating
View Scheme
参考文献
Wardakhan, Wagnat W.; Shams, Hoda Z.; Moustafa, Hosam E.
Phosphorus, Sulfur and Silicon and the Related Elements, 2005 , vol. 180, # 8 p. 1815 - 1827
