4,6-二氨基-2-甲基喹啉合成路线 （共 26 条）
反应条件
sodium hydroxide; acetic acid
参考文献
Lanza, Thomas J.; Durette, Philippe L.; Rollins, Thomas; Siciliano, Salvatore; Cianciarulo, Dana N.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 252 - 258
参考文献
Peng; Daniels
Journal of the American Chemical Society, 1956 , vol. 78, p. 3703,3707
参考文献
Peng; Daniels
Journal of the American Chemical Society, 1956 , vol. 78, p. 3703,3707
反应条件
1: N-tert-butoxycarbonyl-β-alanine With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate in DMF (N,N-dimethyl-formamide)
T=20°C; 0.25 h;
2: 2-methyl-quinoline-4,6-diamine With n-ethyl morpholine in DMF (N,N-dimethyl-formamide)
T=20°C; 24 h;
参考文献
Aventis Pharma Deutschland GmbH; AJINOMOTO CO., INC., Pharmaceutical Company
Patent: EP1369420 A1, 2003 ;
Location in patent: Page 12 ;
参考文献
Pratt; Archer
Journal of the American Chemical Society, 1948 , vol. 70, p. 4065,4069
反应条件
water; sodium acetate
参考文献
I.G. Farbenind.
Patent: DE591480 , 1932 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 20, p. 707,709
