1: 98 percent / H3PO2 aq., AIBN, Et3N / dioxane / 1 h / Heating 2: 96 percent / CAN, pyridine / H2O; acetonitrile / 0.5 h / 0 °C 3: 1) (COCl)2, DMSO, 2) Et3N / 1) CH2Cl2, -78 deg C, 2) CH2Cl2, -78 to 0 deg C 4: 85 percent / CrCl2 / dimethylformamide; tetrahydrofuran / 8 h / Heating 5: 87 percent / nBu4NF*3H2O / tetrahydrofuran / 7 h / Ambient temperature 6: 99 percent / pyridine / 2.5 h / Ambient temperature 7: 1) PdCl2(CH3CN)2, 2) DIBAL, 3) t-BuOK / 1) THF, 2 h, RT, 2) THF, -78 deg C, 14 h, 3) THF, 1 h, RT 8: 93 percent / H3PO4, H2O / tetrahydrofuran / 6 h / 40 °C View Scheme

microsomes of mutton vesicular glands; oxygen in octane; water T=25°C; 1 h; potassium phosphate buffer (pH 7.4) presence, n-octane absence; Product distribution;