3,4-亚甲二氧基-1-苯基-2-硝基丙烯合成路线 （共 10 条）
反应条件
1: Iron; FeCl3; HCl / Heating 2: NaBH3CN / methanol View Scheme
参考文献
Pifl, Christian; Nagy, Gabor; Berenyi, Sandor; Kattinger, Alexandra; Reither, Harald; Antus, Sandor
Journal of Pharmacology and Experimental Therapeutics, 2005 , vol. 314, # 1 p. 346 - 354
反应条件
1: 87 percent / LiAlH4 2: 58 percent / pyridine / 18 h / Ambient temperature 3: LiAlH4 / tetrahydrofuran / 72 h / Heating View Scheme
参考文献
Braun; Shulgin
Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 2 p. 192 - 195
反应条件
hydrogenchloride; iron in methanol; water 0.5 h; Heating;
参考文献
Pradhan, Prasun K.; Dey, Sumit; Jaisankar, Parasuraman; Giri, Venkatachalam S.
Synthetic Communications, 2005 , vol. 35, # 7 p. 913 - 922
反应条件
sulfuric acid; toluene-4-sulfonic acid in methanol T=0 - 5°C; ceramic diaphragm, carbon-rod anode, platinum cathode, 4.5 F/mol, 0.1A, cathode potential -1.45 to -1.65V vs. SCE;
参考文献
Shono, Tatsuya; Hamaguchi, Hiroshi; Mikami, Hiroshi; Nogusa, Hideo; Kashimura, Shigenori
Journal of Organic Chemistry, 1983 , vol. 48, # 12 p. 2103 - 2105
反应条件
1: LAH 2: 90 percent / pyridine / 10 h / Ambient temperature View Scheme
参考文献
Braun; Shulgin
Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 2 p. 192 - 195
反应条件
1: 59 percent / Fe / FeCl3 / conc.HCl / H2O; ethanol / 8 h / Heating
2: 83.45 percent / NaBH4 / methanol / 16 h
View Scheme
参考文献
Bhide, Bhaskar H.; Shah, Kashmira K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 1 p. 9 - 12
反应条件
1: 59 percent / Fe / FeCl3 / conc.HCl / H2O; ethanol / 8 h / Heating
2: 83.45 percent / NaBH4 / methanol / 16 h
3: 83.2 percent / HCl / diethyl ether; H2O / 3 h / 40 °C
4: CrO3 / acetic acid / 3 h / 60 °C
View Scheme
参考文献
Bhide, Bhaskar H.; Shah, Kashmira K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 1 p. 9 - 12
反应条件
1: LiAlH4 / diethyl ether
2: Heating
View Scheme
参考文献
Pifl, Christian; Nagy, Gabor; Berenyi, Sandor; Kattinger, Alexandra; Reither, Harald; Antus, Sandor
Journal of Pharmacology and Experimental Therapeutics, 2005 , vol. 314, # 1 p. 346 - 354
反应条件
piperidine in methanol
1. 1 h/room temperature 2. 2 h/reflux;
参考文献
Niwas, Shri; Kumar, Shiv; Bhaduri, A. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 8 p. 725 - 726
反应条件
aluminium trichloride; acetyl chloride in dichloromethane
T=-30°C; 0.5 h;
参考文献
Kelkar, Shriniwas L.; Phadke, Chetan P.; Marina, Sister
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 5 p. 458 - 459
