4,4-二甲氧基-2-丁酮合成路线 （共 125 条）
反应条件
hydrogen bromide; acetic acid 1.) Et2O, reflux, 16 h, 2.) from 90 deg C to 100 deg C, 2 h; Multistep reaction;
参考文献
Terfort, Andreas; Goerls, Helmar; Brunner, Henri
Synthesis, 1997 , # 1 p. 79 - 86
参考文献
Barton, Derek H. R.; Donnelly, Dervilla M. X.; Finet, Jean-Pierre; Guiry, Patrick J.
Tetrahedron Letters, 1990 , vol. 31, # 51 p. 7449 - 7452
反应条件
magnesium 1.) ether, reflux 2.) 3 h.; Yield given. Multistep reaction;
参考文献
Durrwachter, John R.; Wong, Chi-Huey
Journal of Organic Chemistry, 1988 , vol. 53, # 18 p. 4175 - 4181
参考文献
van Heerden,F.R. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1978 , p. 137 - 145
反应条件
piperidinium acetate pH=9.5; 24 h; Heating;
参考文献
Fischer, Christian B.; Polborn, Kurt; Steininger, Harald; Zipse, Hendrik
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2004 , vol. 59, # 10 p. 1121 - 1131
反应条件
sodium methylate T=170°C;
参考文献
Franke et al.
Chemische Berichte, 1953 , vol. 86, p. 793,795
反应条件
(-)-(R,R)-TADDOL; magnesium 1.) THF, 2.) THF, -78 deg C; Multistep reaction. Yields of byproduct given;
参考文献
Schulz, Stefan; Steffensky, Mirjam; Roisin, Yves
Liebigs Annales, 1996 , # 6 p. 941 - 946
反应条件
1: ethyl acetate With sodium nitrate; acetic acid in water T=0°C; 2: 4,4-dimethoxy-butan-2-one With zinc T=60 - 120°C; 8.33 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; PEER MOHAMED, Shahul, Hameed; WATERSON, David
Patent: WO2010/67125 A1, 2010 ;
Location in patent: Page/Page column 70-71 ;
WO 2010/067125 A1
反应条件
1: With sodium nitrite 2: With zinc Further stages.;
参考文献
Gale, Philip A.; Navakhun, Korakot; Camiolo, Salvatore; Light, Mark E.; Hursthouse, Michael B.
Journal of the American Chemical Society, 2002 , vol. 124, # 38 p. 11228 - 11229
反应条件
ethanol; sodium ethanolate
参考文献
Treibs; Ohorodnik
Justus Liebigs Annalen der Chemie, 1958 , vol. 611, p. 139,148
