3-二甲基氨基-1-(噻吩基)-1-丙酮盐酸盐合成路线 （共 22 条）
反应条件
lithium aluminium tetrahydride; (2S,3R)-(+)-4-Dimethylamino-1,2-diphenyl-3-methyl-2-butanol in tetrahydrofuran; diethyl ether T=-78°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Deeter, Jack; Frazier, Jeff; Staten, Gilbert; Staszak, Mike; Weigel, Leland
Tetrahedron Letters, 1990 , vol. 31, # 45 p. 7101 - 7104
反应条件
1: LiAlH4, (2R,3S)-(+)-4-dimethylamino-1,2-diphenyl-3-methyl-2-butanol / tetrahydrofuran; toluene / 16 h / -70 °C 2: 1) NaH / 1) DMSO, 25 deg C, 25 min 2) 48-72 h, 45-50 deg C View Scheme
参考文献
JUBILANT LIFE SCIENCES LIMITED; BISWAS, Sujay; TRIVEDI, Archana; KHARBANDA, Manlta; DUBEY, Shailendra; SINGLA, Sandeep; YOGIRAJ, Mansukhlal, Bodheka; VIR, Dharam
Patent: WO2011/33366 A2, 2011 ;
反应条件
1.1: sodium hydroxide; sodium tetrahydroborate / water; methanol / 2 h / 35 - 40 °C 2.1: sodium hydride / dimethyl sulfoxide / 20 °C 2.2: 48 - 50 °C 2.3: 5 h / 20 °C 3.1: sodium hydroxide / toluene; water / 20 - 45 °C / pH 11 - 12 4.1: N-ethyl-N,N-diisopropylamine / toluene / 2 h / 15 - 20 °C 4.2: 1 h / 40 - 45 °C 5.1: potassium hydroxide / toluene / 7 h / 80 - 85 °C 5.2: 0 - 5 °C View Scheme
参考文献
JUBILANT LIFE SCIENCES LIMITED; BISWAS, Sujay; TRIVEDI, Archana; KHARBANDA, Manlta; DUBEY, Shailendra; SINGLA, Sandeep; YOGIRAJ, Mansukhlal, Bodheka; VIR, Dharam
Patent: WO2011/33366 A2, 2011 ;
反应条件
1: ammonium hydroxide / ethanol 2: sodium cyanide View Scheme
参考文献
Abashev; Begishev; Bushueva; Romanova; Shklyaeva
Russian Journal of Applied Chemistry, 2010 , vol. 83, # 8 p. 1440 - 1443
反应条件
sodium hydroxide in water T=20°C;
参考文献
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China
Patent: EP2305669 A1, 2011 ;
Location in patent: Page/Page column 6 ;
反应条件
ammonium acetate 1.) acetic acid, 100 deg C, 10 min, 2.) 105 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Constable, Edwin C.; Henney, Roland P. G.; Tocher, Derek A.
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1992 , # 16 p. 2467 - 2474
反应条件
1: water 2: aqueous hydrochloric acid View Scheme
参考文献
Knott
Journal of the Chemical Society, 1947 , p. 1196,1200
反应条件
1: sodium tetrahydroborate; sodium hydroxide / water / 7 h / 20 - 71 °C 2: toluene / 0.5 h / 80 °C 3: sodium hydroxide / water 4: sodium hydrogencarbonate / toluene / 90 °C 5: sodium hydrogencarbonate / toluene / 0.33 h / 120 °C / |Dean-Stark 6: sodium hydroxide / water; ethanol / 3 h / 82 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 10, # 5 p. 905 - 913
反应条件
ammonium acetate in acetic acid 100 deg C 10 min, 105 deg C 4 h;
参考文献
Constable, Edwin C.; Henney, Roland P. G.; Leese, Troy A.
Journal of Organometallic Chemistry, 1989 , vol. 361, p. 277 - 282
参考文献
Kroehnke,F.
Synthesis, 1976 , p. 1 - 24
