3-氨基吡嗪-2-羧酸合成路线

参考文献

THE SCRIPPS RESEARCH INSTITUTE
Patent: WO2008/115369 A2, 2008 ;
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WO 2008/115369 A2

5424-01-13-氨基吡嗪-2-羧酸+

74-89-5甲胺

36204-76-93-氨基-n-甲基吡嗪-2-羧酰胺

参考文献

Naito, Youichiro; Akahoshi, Fumihiko; Takeda, Shinji; Okada, Takehiro; Kajii, Masahiko; Nishimura, Hiroko; Sugiura, Masanori; Fukaya, Chikara; Kagitani, Yoshio
Journal of Medicinal Chemistry, 1996 , vol. 39, # 15 p. 3019 - 3029

2525-16-81-氮杂-2-甲氧基-1-环庚烯+

5424-01-13-氨基吡嗪-2-羧酸

16298-03-63-氨基吡嗪-2-羧酸甲酯+

36120-38-4

参考文献

Dunn; Kinnear; Norrie
Zeitschrift fur Chemie, 1986 , vol. 26, # 8 p. 290 - 292

5424-01-13-氨基吡嗪-2-羧酸

13301-04-73,6-二溴吡嗪-2-甲酸甲酯

参考文献

Andrews, Martin J.I.; Andrew Clase; Bar, Gregory; Tricarico, Giovanni; Edwards, Paul J.; Brys, Reginald; Chambers, Mark; Schmidt, Wolfgang; MacLeod, Angus; Hirst, Kim; Allen, Vivienne; Birault, Veronique; Le, Joelle; Harris, John; Self, Andrew; Nash, Kevin; Dixon, Graham
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 6 p. 2266 - 2270

5424-01-13-氨基吡嗪-2-羧酸

17890-77-63-氨基-6-溴吡嗪-2-甲酰胺

参考文献

Duan, Chonggang; Jia, Jiong; Zhu, Rongxiu; Wang, Jianwu
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5424-01-13-氨基吡嗪-2-羧酸

25911-65-33-氨基吡嗪-2-甲腈

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Ellingson et al.
Journal of the American Chemical Society, 1945 , vol. 67, p. 1711

67-56-1甲醇+

5424-01-13-氨基吡嗪-2-羧酸

16298-03-63-氨基吡嗪-2-羧酸甲酯

参考文献

Forns, Pilar; Esteve, Cristina; Taboada, Lorena; Alonso, Juan Antonio; Orellana, Adelina; Maldonado, Monica; Carreno, Cristina; Ramis, Isabel; Lopez, Manel; Miralpeix, Montserrat; Vidal, Bernat
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2784 - 2788

5424-01-13-氨基吡嗪-2-羧酸

16298-03-63-氨基吡嗪-2-羧酸甲酯

参考文献

American Cyanamid Company
Patent: US5252538 A1, 1993 ;

5693-62-96-甲氧基-2,3,4,5-四氢吡啶+

5424-01-13-氨基吡嗪-2-羧酸

16298-03-63-氨基吡嗪-2-羧酸甲酯+

35982-77-5

参考文献

Dunn; Kinnear; Norrie
Zeitschrift fur Chemie, 1986 , vol. 26, # 8 p. 290 - 292

2525-16-81-氮杂-2-甲氧基-1-环庚烯+

5424-01-13-氨基吡嗪-2-羧酸