反应条件
1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 1.5 h / 75 °C 2: palladium 10 on activated carbon; ammonium formate / methanol; water / 4 h / 75 °C / |Inert atmosphere View Scheme
参考文献
GALAPAGOS NV; MENET, Christel; SCHMITT, Benoît; GENEY, Raphaël; DOYLE, Kevin; PEACH, Joanne; PALMER, Nicholas; JONES, Graham; HARDY, David; DUFFY, James
Patent: WO2013/117649 A1, 2013 ;