1: 6-bromo-2-methoxypyridine With n-butyllithium in tetrahydrofuran T=-78°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran Further stages.;

1.1: 50 percent / methanol; dimethylformamide / 2 h / 80 °C 2.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C 2.2: 53 percent / hexane; tetrahydrofuran / 1 h / -78 - 20 °C View Scheme

1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; cyclohexane T=0°C; 0.333333 h; 2: 6-methoxypyridine-2-carboxaldehyde in tetrahydrofuran; cyclohexane T=0 - 20°C; 0.5 h;

View Scheme

Yield given. Multistep reaction. Yields of byproduct given;