(4,6-二甲基-2-嘧啶基)甲醇合成路线 （共 8 条）
反应条件
trichlorophosphate in chloroform 3 h; Heating;
参考文献
Sakamoto, Takao; Tanji, Ken-Ichi; Niitsuma, Setsuko; Ono, Takayasu; Yamanaka, Hiroshi
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 11 p. 3362 - 3368
反应条件
1: 90 percent / POCl3 / CHCl3 / 3 h / Heating 2: 84 percent / ethanol; H2O / 1.5 h / Heating View Scheme
参考文献
Sakamoto, Takao; Tanji, Ken-Ichi; Niitsuma, Setsuko; Ono, Takayasu; Yamanaka, Hiroshi
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 11 p. 3362 - 3368
反应条件
water; sodium hydroxide in ethanol
T=80°C; 18 h;
参考文献
ARROW THERAPEUTICS LIMITED; ASTRAZENECA UK LIMITED; BARNES, Michael, Christopher, Stratton; FLACK, Stephen, Sean; FRASER, Ian; LUMLEY, James, Andrew; PANG, Pui Shan; SPENCER, Keith, Charles; TIBERGHIEN, Nathalie, Anne, Laure; TOMKINSON, Gary, Peter
Patent: WO2011/151651 A1, 2011 ;
Location in patent: Page/Page column 78-79 ;
WO 2011/151651 A1
反应条件
sodium tetrahydroborate; ethanol
T=0 - 20°C; Inert atmosphere;
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;
Location in patent: Paragraph 0589; 0590; 0591 ;
反应条件
(NH4)2S2O8; sulfuric acid in water
5 h; Heating;
参考文献
Sakamoto, Takao; Tanji, Ken-Ichi; Niitsuma, Setsuko; Ono, Takayasu; Yamanaka, Hiroshi
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 11 p. 3362 - 3368
反应条件
1: N,N-dimethyl-formamide / 4 h / 80 °C
2: sodium hydroxide; water / ethanol / 18 h / 80 °C
View Scheme
参考文献
ARROW THERAPEUTICS LIMITED; ASTRAZENECA UK LIMITED; BARNES, Michael, Christopher, Stratton; FLACK, Stephen, Sean; FRASER, Ian; LUMLEY, James, Andrew; PANG, Pui Shan; SPENCER, Keith, Charles; TIBERGHIEN, Nathalie, Anne, Laure; TOMKINSON, Gary, Peter
Patent: WO2011/151651 A1, 2011 ;
WO 2011/151651 A1
反应条件
1: palladium(II) dichloride bis[bis(diphenylphosphine)ferrocene]; triethylamine / acetonitrile / 20 - 100 °C / |Inert atmosphere
2: sodium tetrahydroborate; ethanol / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;
反应条件
selenium(IV) oxide in 1,4-dioxane
1 h; Heating;
参考文献
Sakamoto, Takao; Tanji, Ken-Ichi; Niitsuma, Setsuko; Ono, Takayasu; Yamanaka, Hiroshi
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 11 p. 3362 - 3368
