2-(1-乙氧基亚乙基)丙二腈合成路线 (共 53 条)
反应条件
1: Na, EtOH / 2 h
2: H2, HCO2H / Raney nickel / 3 h / 2585.7 Torr / Ambient temperature
View Scheme
参考文献
Bennett, Lawrence R.; Blankley, C. John; Fleming, Robert W.; Smith, Ronald D.; Tessman, Deirdre K.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 4 p. 382 - 389
反应条件
in ethanol
3 h; Heating;
参考文献
Kreutzberger; Burgwitz
Archiv der Pharmazie, 1980 , vol. 313, # 11 p. 906 - 912
反应条件
sodium acetate in ethanol
1 h; Reflux;
参考文献
Faria, Jessica V.; Dos Santos, Mauricio S.; Bernardino, Alice M.R.; Becker, Klaus M.; Machado, Gerzia M.C.; Rodrigues, Raquel F.; Canto-Cavalheiro, Marilene M.; Leon, Leonor L.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 23 p. 6310 - 6312
反应条件
in ethanol
3 h; Heating;
参考文献
Kreutzberger; Burgwitz
Archiv der Pharmazie, 1980 , vol. 313, # 11 p. 906 - 912
反应条件
1: 93 percent / ethanol / 3 h / Heating
2: 79 percent / 1 h / Heating
View Scheme
参考文献
Kreutzberger; Burgwitz
Archiv der Pharmazie, 1980 , vol. 313, # 11 p. 906 - 912
反应条件
1: NH2OH*HCl, aq. NaOH
2: (i) H2SO4, (ii) aq. NH3
3: Ac2O / 3 h / Heating
View Scheme
参考文献
Taylor,E.C.; Garcia,E.E.
Journal of Organic Chemistry, 1964 , vol. 29, p. 2116 - 2120
反应条件
1: NH2OH*HCl, aq. NaOH
2: Ac2O / 4 h / Heating
View Scheme
参考文献
Taylor,E.C.; Garcia,E.E.
Journal of Organic Chemistry, 1964 , vol. 29, p. 2116 - 2120
反应条件
potassium acetate in ethanol
2 h; Heating;
参考文献
Saito, Koji; Kambe, Satoshi; Sakurai, Akio; Midorikawa, Hiroshi
Synthesis, 1982 , # 12 p. 1056 - 1059
反应条件
1: NH2OH*HCl, aq. NaOH
2: (i) Ac2O, (ii) NH3, EtOH
View Scheme
参考文献
Taylor,E.C.; Garcia,E.E.
Journal of Organic Chemistry, 1964 , vol. 29, p. 2116 - 2120
反应条件
1: With sodium methylate in methanol
T=0 - 20°C;
2: With water in methanol
0.5 h;
参考文献
SMITHKLINE BEECHAM CORPORATION; ATKINSON, Francis, Louis; AXTEN, Jeffrey, Michael; CICHY-KNIGHT, Maria; MOORE, Michael, Lee; PATEI, Vipulkumar, Kantibhai; TIAN, Xinrong; WELLAWAY, Christopher, Roland; DUNN, Allison, K.
Patent: WO2010/19637 A1, 2010 ;
Location in patent: Page/Page column 54 ;
WO 2010/019637 A1