1: 2-bromo-4-phenylpyridine With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: 1-piperidinecarboxaldehyde in tetrahydrofuran; hexane
T=-78 - 0°C; 2 h;
3: With hydrogenchloride; water in tetrahydrofuran; hexane
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2005/123680 A1, 2005 ;
Location in patent: Page/Page column 77 ;
WO 2005/123680 A1
