4,6-二氯-5-氨基嘧啶合成路线

4316-93-24,6-二氯-5-硝基嘧啶→5413-85-44,6-二氯-5-氨基嘧啶

参考文献

Latli, Bachir; Jones, Paul-James; Krishnamurthy, Dhileepkumar; Senanayake, Chris H.
Journal of Labelled Compounds and Radiopharmaceuticals, 2008 , vol. 51, # 1 p. 54 - 58

69340-97-25-氨基-4,6-二羟基嘧啶→5413-85-44,6-二氯-5-氨基嘧啶

参考文献

ENANTIA, S.L.; PASTÓ AGUILÀ, Mireia; COMELY, Alexander Christian
Patent: WO2014/23681 A1, 2014 ;
Location in patent: Page/Page column 33; 34 ;

5413-85-44,6-二氯-5-氨基嘧啶+17518-49-92-(2,6-二氯苯基)硫代乙酰胺→3215-64-32,6-二氯苯乙腈+1160608-75-2

参考文献

Liu, Jing; Fitzgerald, Anne E.; Lebsack, Alec D.; Mani, Neelakandha S.
Organic Process Research and Development, 2011 , vol. 15, # 2 p. 382 - 388

5413-85-44,6-二氯-5-氨基嘧啶→4316-98-76-氯-4,5-嘧啶二胺

参考文献

ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB
Patent: WO2007/125325 A1, 2007 ;
Location in patent: Page/Page column 92-93 ;
WO 2007/125325 A1

5413-85-44,6-二氯-5-氨基嘧啶→42786-59-44-氯-5-氨基-6-肼基嘧啶

参考文献

Crowley, Patrick J.; Lamberth, Clemens; Mueller, Urs; Wendeborn, Sebastian; Sageot, Olivia-A.; Williams, John; Bartovic, Alexander
Tetrahedron Letters, 2010 , vol. 51, # 19 p. 2652 - 2654

5413-85-44,6-二氯-5-氨基嘧啶+107-11-9丙烯胺→181304-94-9

参考文献

Konkel, Michael J.; Vince, Robert
Journal of Organic Chemistry, 1996 , vol. 61, # 18 p. 6199 - 6204

5413-85-44,6-二氯-5-氨基嘧啶+7087-68-5N,N-二异丙基乙胺+2450-71-7炔丙胺→181304-94-9

参考文献

Eisai Co., Ltd.
Patent: EP1221444 A1, 2002 ;

5413-85-44,6-二氯-5-氨基嘧啶+33966-50-6丁胺→195252-58-5

参考文献

Kelley, James L.; Morris Bullock; Krochmal, Mark P.; McLean, Ed W.; Linn, James A.; Durcan, Micheal J.; Cooper, Barrett R.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 20 p. 3207 - 3216

5413-85-44,6-二氯-5-氨基嘧啶→23722-96-5

参考文献

Frick; Patil; Gambino; Schneller
Tetrahedron Letters, 1993 , vol. 34, # 35 p. 5541 - 5544

107-10-8正丙胺+5413-85-44,6-二氯-5-氨基嘧啶→195252-56-36-氯-N4-丙基-4,5-嘧啶二胺

参考文献

Journal of Medicinal Chemistry, , vol. 40, # 20 p. 3207 - 3216