5,6-二氯-3-吡啶甲醇合成路线 （共 10 条）
反应条件
1: With borane-THF in tetrahydrofuran T=0 - 20°C; 2: With water; potassium carbonate in tetrahydrofuran Saturated solution;
参考文献
Bayer CropScience AG
Patent: US2010/48646 A1, 2010 ;
Location in patent: Page/Page column 25 ;
反应条件
sodium hydrogencarbonate in tetrahydrofuran; n-heptane; ethyl acetate
参考文献
The Institutes for Pharmaceutical Discovery, Inc. A Corporation of the State of Delaware
Patent: US2003/166668 A1, 2003 ;
反应条件
sodium borohydride in water
参考文献
US4115575 A1, ;
US 4115575 A
US4410530 A1, ;
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2>134, p. 177,184
反应条件
1: xylene; palladium/barium sulfate / 160 - 170 °C / Hydrogenation 2: aqueous KOH-solution View Scheme
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2>134, p. 177,184
反应条件
pyridine; thionyl chloride T=0 - 20°C; 2 h;
参考文献
Ube Industries, Ltd.; SANTEN PHARMACEUTICAL CO., LTD.
Patent: EP1679308 A1, 2006 ;
Location in patent: Page/Page column 35 ;
EP 1679308 A1
反应条件
manganese(IV) oxide in dichloromethane T=25°C; 48 h;
参考文献
Tafesse, Laykea
Patent: US2010/120862 A1, 2010 ;
Location in patent: Page/Page column 94 ;
US 20100120862 A1
反应条件
in methanol Heating / reflux;
参考文献
CONFORMA THERAPEUTICS CORPORATION
Patent: WO2005/28434 A2, 2005 ;
Location in patent: Page/Page column 310 ;
反应条件
tin(ll) chloride in chloroform
T=20°C; 63 h;
参考文献
MOCHIDA PHARMACEUTICAL CO., LTD.
Patent: EP1908753 A1, 2008 ;
Location in patent: Page/Page column 102-103 ;
参考文献
Ciba-Geigy Corporation
Patent: US4115575 A1, 1978 ;
US 4115575 A
