5-甲基-1(3h)-异苯并呋喃酮合成路线 （共 20 条）
反应条件
4-(N,N-dimethlyamino)pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; N-ethyl-N,N-diisopropylamine; palladium diacetate in 1,4-dioxane
T=180°C; 0.5 h; microwave irradiation;
参考文献
Wu, Xiongyu; Mahalingam; Wan, Yiqian; Alterman, Mathias
Tetrahedron Letters, 2004 , vol. 45, # 24 p. 4635 - 4638
反应条件
calcium hydroxide powder; hydrogen; palladium on activated charcoal in 1,4-dioxane
P=2068.6 Torr; 48 h;
参考文献
Neudeck
Monatshefte fur Chemie, 1996 , vol. 127, # 2 p. 201 - 217
反应条件
piperidine in acetonitrile
2 h; Ambient temperature;
参考文献
Padwa, Albert; Bullock, William H.; Norman, Bryan H.; Perumattam, John
Journal of Organic Chemistry, 1991 , vol. 56, # 13 p. 4252 - 4259
反应条件
Sodium bromate; sodium hydrogensulfite in water; ethyl acetate
T=20°C; 40 h;
参考文献
Bayer, Ernst; Hayat, Safdar; Atta-Ur-Rahman; Choudhary, M. Iqbal; Khan, Khalid Mohammed; Shah, Syed Tasadaque Ali; Imran-Ul-Haq; Anwar, M. Usman; Voelter, Wolfgang
Arzneimittel-Forschung/Drug Research, 2005 , vol. 55, # 10 p. 588 - 597
反应条件
1: With silver hexafluoroantimonate; [RhCl(η2:η2-cycloocta-1,5-diene)]2; hexafluoroisopropyl alcohol
T=20°C; intramolecular Diels-Alder reaction; 1 h;
2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone
参考文献
Saito, Akio; Ono, Takamitsu; Takahashi, Arata; Taguchi, Takeo; Hanzawa, Yuji
Tetrahedron Letters, 2006 , vol. 47, # 6 p. 891 - 895
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
3.5 h; Heating;
参考文献
Dawson; Hobbs; Chan; Chao; Fung
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 583 - 592
反应条件
palladium on activated charcoal in 1,2-dichloro-benzene
48 h; Heating;
参考文献
Noguchi, Michihiko; Kakimoto, Shinji; Kawakami, Hisao; Kajigaeshi, Shoji
Heterocycles, 1985 , vol. 23, # 5 p. 1085 - 1088
反应条件
dipotassium hydrogenphosphate; palladium diacetate
T=140°C; 36 h;
参考文献
Zhang, Yang-Hui; Shi, Bing-Feng; Yu, Jin-Quan
Angewandte Chemie, International Edition, 2009 , vol. 48, # 33 p. 6097 - 6100
Angewandte Chemie, 2009 , vol. 121, # 33 p. 6213 - 6216
反应条件
palladium diacetate; sodium hydrogencarbonate
T=140°C; 36 h;
参考文献
Zhang, Yang-Hui; Shi, Bing-Feng; Yu, Jin-Quan
Angewandte Chemie, International Edition, 2009 , vol. 48, # 33 p. 6097 - 6100
Angewandte Chemie, 2009 , vol. 121, # 33 p. 6213 - 6216
反应条件
1: NBS, benzoyl peroxide / CCl4 / 3 h / Heating
2: 1 h / 180 °C / 10 Torr
3: 83 percent / H2, Ca(OH)2 / 10percent Pd/C / dioxane / 48 h / 2068.6 Torr
View Scheme
参考文献
Neudeck
Monatshefte fur Chemie, 1996 , vol. 127, # 2 p. 201 - 217
