AlCl3, aluminium chloride in dichloromethane T=20°C; Inert atmosphere;

potassium phosphate; platinacycle; pentan-3-one in toluene T=90 - 100°C;

1: 3-bromophenylacetic acid With oxalyl dichloride; N,N-dimethyl-formamide in benzene T=20°C; Substitution; 3 h; 2: methoxybenzene With aluminium trichloride in carbon disulfide T=20°C; Condensation; Friedel-Crafts reaction; 3 h;

1: 72 percent / AlCl3 / benzene / 2 h / Heating 2: 80 percent / PPh3; Et3N; Pd(OAc)2 / 5 h / Heating 3: 40 percent / Pd(PPh3)4; 18-crown-6 / benzene / 2 h / Heating 4: 92 percent / TBAF; AcOH / tetrahydrofuran / 2 h / 20 °C View Scheme