in hexane; water
to a soln. of (Et3Sn)2O in hexane was added imide in water (molar ratiooxide/imide = 1/2); shaking at room temp. for 15-20 min, org. layer wasseparated, water layer washed with hexane; org. layers were combined; drying over MgSO4, evapn., crystn. from hexane or pentane;
参考文献
Razuvaev, G. A.; Shcherbakov, V. I.; Stolyarova, N. E.
Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 1983 , vol. 13, p. 59 - 66
1: 4-trifluoromethylaniline With hydrogenchloride in water
T=20°C; 0.5 h;
2: With sodium nitrite in water
T=0°C;
3: maleic imide With sodium acetate; copper dichloride in water; acetone
T=0 - 20°C; pH=3 - 3.5;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/22980 A1, 2007 ;
Location in patent: Page/Page column 36 ;
1: 4-trifluoromethylaniline With hydrogenchloride in water
0.5 h;
2: With sodium nitrite in water
T=0°C;
3: maleic imide With sodium acetate; copper dichloride in water; acetone
T=0°C; pH=3 - 3.5;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/136223 A1, 2006 ;
Location in patent: Page/Page column 30 ;
WO 2006/136223 A1
