4-溴-3,5-二甲基-1H-吡咯-2-羧酸乙酯合成路线 （共 13 条）
反应条件
1: acetic acid; bromine / anschliessendes Behandeln mit SO2Cl2 und Erwaermen des erhaltenen Reaktionsgemisches mit H2O 2: ethanolic KOH 3: palladium/ magnesium oxide / coal catalyst; methanol / Hydrogenation 4: ethanolic NaOH 5: glycerol View Scheme
参考文献
Corwin; Straughn
Journal of the American Chemical Society, 1948 , vol. 70, p. 1416,1420
反应条件
1: acetic acid; bromine / anschliessendes Behandeln mit SO2Cl2 und Erwaermen des erhaltenen Reaktionsgemisches mit H2O 2: ethanolic KOH 3: palladium/ magnesium oxide / coal catalyst; methanol / Hydrogenation View Scheme
参考文献
Corwin; Straughn
Journal of the American Chemical Society, 1948 , vol. 70, p. 1416,1420
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide Heating;
参考文献
Chang, C. K.; Bag, Nilkamal
Journal of Organic Chemistry, 1995 , vol. 60, # 21 p. 7030 - 7032
参考文献
Canadian Patents and Development Limited
Patent: US4070366 A1, 1978 ;
反应条件
pyridine; bromine in dichloromethane
T=5°C; 0.25 h;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2005/56004 A1, 2005 ;
Location in patent: Page/Page column 51; 125 ;
反应条件
chlorine in dichloromethane
T=-20°C;
参考文献
Angelini, Giancarlo; Illuminati, Gabriello; Monaci, Anna; Sleiter, Giancarlo; Speranza, Maurizio
Journal of the American Chemical Society, 1980 , vol. 102, # 4 p. 1377 - 1382
反应条件
copper(ll) bromide in 1,4-dioxane
T=80°C; 3 h;
参考文献
Monti, Donato; Sleiter, Giancarlo
Gazzetta Chimica Italiana, 1990 , vol. 120, p. 771 - 774
反应条件
in 1,4-dioxane
byproducts: ethyl 3,5-dimethylpyrrole-2-carboxylate; addn. soln. of Tl compound to soln. of Cu(II) compound, stirring (3 h, 80°C); cooling, filtration off inorganic salts, filtrate washing (dioxane), extn. (Et2O), drying (Na2SO4); m. p.;
参考文献
Monti, Donato; Sleiter, Giancarlo
Gazzetta Chimica Italiana, 1990 , vol. 120, p. 771 - 774
参考文献
Fischer; Ernst
Justus Liebigs Annalen der Chemie, 1926 , vol. 447, p. 153
反应条件
sodium acetate; acetic acid
参考文献
Fischer et al.
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1943 , vol. 279, p. 1,19
