2-氨基-4,6-二甲基吡啶合成路线 （共 43 条）
反应条件
1: With bromine; acetic acid
T=20°C; 1.25 h; Inert atmosphere;
2: With sodium hydroxide
Inert atmosphereCooling with ice;
参考文献
Zhang, Feng; Zaidi, Saheem; Haney, Kendra M.; Kellogg, Glen E.; Zhang, Yan
Journal of Organic Chemistry, 2011 , vol. 76, # 19 p. 7945 - 7952
反应条件
in 1,2-dichloro-ethane
T=60°C; 3 h;
参考文献
Bouhayat, Said; Piessard, Sylvie; Baut, Guillaume Le; Sparfel, Louis; Petit, Jean-Yves; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 555 - 559
反应条件
1: 59 percent / bromine; glacial acetic acid / 1.33 h / 20 °C
2: 64 percent / potassium nitrate; concd. sulfuric acid / 1 h / 20 °C
3: 98 percent / hydrogen; ammonium hydroxide / palladium on carbon / methanol / 18 h / 50 °C / 2585.74 Torr
4: 49 percent / potassium carbonate / acetone / 18 h / 20 °C
5: lithium aluminum hydride / tetrahydrofuran / 1 h / Heating
6: 75 mg / methanol / 6 h / 120 °C
View Scheme
参考文献
Tanga; Bradford; Bupp; Kozocas
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 4 p. 569 - 573
