2-氨基-4,6-二甲基吡啶合成路线 （共 43 条）
反应条件
1: With sulfuric acid; nitric acid 2: With water; nitric acid
参考文献
Hartz, Richard A.; Ahuja, Vijay T.; Schmitz, William D.; Molski, Thaddeus F.; Mattson, Gail K.; Lodge, Nicholas J.; Bronson, Joanne J.; Macor, John E.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 6 p. 1890 - 1894
反应条件
sulfuric acid; nitric acid
参考文献
Sawanishi, Hiroyuki; Tajima, Kayoko; Tsuchiya, Takashi
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 10 p. 4101 - 4109
反应条件
nitric acid in conc. H2 SO4
参考文献
Horizons Incorporated, a division of Horizons Research Incorporated
Patent: US4000146 A1, 1976 ;
反应条件
HIO4*2H2O; sulfuric acid; iodine; acetic acid in water T=80°C; 4 h;
参考文献
Nara, Susheel J.; Jha, Mukund; Brinkhorst, Johan; Zemanek, Tony J.; Pratt, Derek A.
Journal of Organic Chemistry, 2008 , vol. 73, # 23 p. 9326 - 9333
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin in dichloromethane T=-5°C; 1.5 h; Inert atmosphere; regioselective reaction;
参考文献
Crawford, Jason B.; Chen, Gang; Carpenter, Bryon; Wilson, Trevor; Ji, Jenny; Skerlj, Renato T.; Bridger, Gary J.
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 109 - 116
参考文献
Merck and Co. Inc.
Patent: US5693812 A1, 1997 ;
US 5693812 A
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin in dichloromethane T=-50°C; 0.5 h; Yields of byproduct given;
参考文献
Heitsch, Holger; Becker, Reinhard H.A.; Kleemann, Heinz-Werner; Wagner, Adalbert
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 4 p. 673 - 678
反应条件
1: 92 percent / 1,3-dibromo-5,5-dimethylhydantoin / CH2Cl2 / 0.5 h / -50 °C 2: 95 percent / HNO3, H2SO4 / 0.5 h / -10 - 20 °C 3: 85 percent / ammonium formate, 10percent Pd/C / methanol / 4 h / Heating 4: 69 percent / polyphosphoric acid / 5 h / 100 °C View Scheme
参考文献
Heitsch, Holger; Becker, Reinhard H.A.; Kleemann, Heinz-Werner; Wagner, Adalbert
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 4 p. 673 - 678
反应条件
triethylamine in benzene T=25°C; 2 h;
参考文献
Hermecz, Istvan; Horvath, Agnes; Vasvari-Debreczy, Lelle; Meszaros, Zoltan
Synthesis, 1984 , # 2 p. 152 - 158
反应条件
sulfuric acid; sodium nitrite
参考文献
Lecocq
Bulletin de la Societe Chimique de France, 1950 , p. 188,190
