N,N-二甲氨基氯丙烷盐酸盐合成路线 （共 48 条）
反应条件
sulfuryl dichloride in chloroform T=0°C; 5 h; Reflux;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
Location in patent: Paragraph 0248 ;
反应条件
1: 4 h; Reflux; 2: With thionyl chloride in tetrachloromethane T=20°C; 4 h; Cooling with ice;
参考文献
CHINA PHARMACEUTICAL UNIVERSITY; Xiang, Hua; Wang, Tianlin; Xiao, Hong; You, Qidong; Yao, Yao; Li, Xiaobo; Liao, Qingjiang
Patent: US2013/85140 A1, 2013 ;
Location in patent: Paragraph 0058; 0059 ;
反应条件
formic acid 30 h; Heating;
参考文献
Habtemanam, Abraha; Watchman, Beth; Potter, Brian S.; Palmer, Rex; Parsons, Simon; Parkin, Andrew; Sadler, Peter J.
Journal of the Chemical Society. Dalton Transactions, 2001 , # 8 p. 1306 - 1318
反应条件
caesium carbonate in N,N-dimethyl-formamide T=80°C; 20 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/122765 A1, 2008 ;
Location in patent: Page/Page column 94 ;
WO 2008/122765 A1
反应条件
caesium carbonate in N,N-dimethyl-formamide T=100°C; 2.5 h; Inert atmosphere;
参考文献
Pan, Xiaoyan; Dong, Jinyun; Gao, Hongping; Wang, Fang; Zhang, Yanmin; Wang, Sicen; Zhang, Jie
Chemical Biology and Drug Design, 2014 , vol. 83, # 5 p. 592 - 599
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 48 h;
参考文献
INHIBOX LTD.
Patent: WO2008/142376 A1, 2008 ;
Location in patent: Page/Page column 67; 85-86 ;
WO 2008/142376 A1
反应条件
1: With potassium hydroxide in water T=0 - 5°C; 2: With iodine; magnesium in tetrahydrofuran T=100 - 110°C; 4 h; Reflux;
参考文献
L. MOLTENI and C. DEI FRATELLI ALITTI - SOCIETA' DI ESERCIZIO S.P.A.; DEI, Donata; RONCUCCI, Gabrio; SOLDAINI, Gianluca; NISTRI, Daniele; CHITI, Giacomo; MUNICCHI, Moira; FANTETTI, Lia; GIULIANI, Francesco
Patent: WO2013/21338 A1, 2013 ;
Location in patent: Page/Page column 10; 11 ;
反应条件
potassium carbonate in dimethyl sulfoxide T=20°C; 16 h;
参考文献
Bentzien, Joerg Martin; Takahashi, Hidenori
Patent: US2008/261975 A1, 2008 ;
Location in patent: Page/Page column 12 ;
反应条件
1: 66 percent / Cs2CO3; NaI / acetonitrile / 12 h / 65 °C 2: 70 percent / tetrabutylammonium bromide; KOAc; molecular sieves 4 Angstroem / Pd(OAc)2 / dimethylformamide / 8 h / 20 °C 3: 95 percent / KOH / methanol; H2O / 12 h / 20 °C View Scheme
参考文献
Georgiades, Savvas N.; Clardy, Jon
Organic Letters, 2006 , vol. 8, # 19 p. 4251 - 4254
反应条件
caesium carbonate in N,N-dimethyl-formamide T=50°C; 18 h;
参考文献
Patt, William C.; Cheng, Xue-Min; Repine, Joseph T.; Lee, Chet; Reisdorph, Bill R.; Massa, Mark A.; Doherty, Annette M.; Welch, Kathleen M.; Bryant, John W.; Flynn, Michael A.; Walker, Donnelle M.; Schroeder, Richard L.; Haleen, Stephen J.; Keiser, Joan A.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 12 p. 2162 - 2168
