3-(4-甲氧苯基)-1-丙醇合成路线 （共 74 条）
反应条件
1: pyridinium chlorochromate / dichloromethane
2: sodium hydride / tetrahydrofuran
3: hydrogen; palladium on activated charcoal / ethyl acetate
4: sodium hydroxide / ethanol
View Scheme
参考文献
Mimori, Seisuke; Okuma, Yasunobu; Kaneko, Masayuki; Kawada, Koichi; Nomura, Yasuyuki; Murakami, Yasuoki; Hamana, Hiroshi
Chemistry Letters, 2013 , vol. 42, # 9 p. 1051 - 1052
反应条件
1: 81 percent / pyridine / 4 h / 0 °C
2: LiBr / acetone / 24 h
3: 1.) thiourea, 2.) 10percent NaOH / 1.) EtOH, reflux, 4 h, 2.) H2O, 80 deg C, 2 h
4: 71 percent / Na, EtOH / 1.5 h / Heating
View Scheme
参考文献
Mohamed, Salah E.N.; Whiting, Donald A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 10 p. 2577 - 2582
反应条件
1: 81 percent / pyridine / 4 h / 0 °C
2: LiBr / acetone / 24 h
3: 1.) thiourea, 2.) 10percent NaOH / 1.) EtOH, reflux, 4 h, 2.) H2O, 80 deg C, 2 h
4: 71 percent / Na, EtOH / 1.5 h / Heating
5: 58 percent / m-chloroperbenzoic acid / CH2Cl2 / 6 h
View Scheme
参考文献
Mohamed, Salah E.N.; Whiting, Donald A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 10 p. 2577 - 2582
反应条件
NiCl2(phenyldi(cyclohexyl)phosphine)2 in diethyl ether
T=80°C; 15 h;
参考文献
Dankwardt, John W.
Angewandte Chemie - International Edition, 2004 , vol. 43, # 18 p. 2428 - 2432
反应条件
1: PBr3 / benzene
2: Mg / diethyl ether / Heating
3: CrO3, aq. AcOH
View Scheme
参考文献
Delobelle,J.; Fetizon,M.
Bulletin de la Societe Chimique de France, 1961 , p. 1894 - 1900
反应条件
1: PBr3 / benzene
2: Mg / diethyl ether / Heating
View Scheme
参考文献
Delobelle,J.; Fetizon,M.
Bulletin de la Societe Chimique de France, 1961 , p. 1894 - 1900
反应条件
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / |Inert atmosphere
1.2: 0.33 h / 20 °C / |Inert atmosphere
2.1: toluene / 0.33 h / |Inert atmosphere; |Reflux
3.1: hydrogen; palladium on activated charcoal / ethanol / 10 h / 20 °C / |Inert atmosphere
4.1: hydrogen bromide / acetic acid / 3 h / |Inert atmosphere; |Reflux
View Scheme
参考文献
Thuaud, Frederic; Kojima, Shuntaro; Hirai, Go; Oonuma, Kana; Tsuchiya, Ayako; Uchida, Takako; Tsuchimoto, Teruhisa; Sodeoka, Mikiko
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 9 p. 2771 - 2782
反应条件
1: 83 percent / chromium trioxide, pyridine / CH2Cl2 / 0.17 h / 25 °C
2: 86 percent / 1.) sodium hydride, Me2SO / 1.) 65 deg C, 1.5 h, 2.) THF, 0 deg C, 0.5 h; 25 deg C, 2 h
View Scheme
参考文献
Semmelhack, M.F.; Helquist, Paul; Jones, L.D.; Keller, Leonard; Mendelson L.; et al.
Journal of the American Chemical Society, 1981 , vol. 103, # 21 p. 6460 - 6471
反应条件
1: 83 percent / chromium trioxide, pyridine / CH2Cl2 / 0.17 h / 25 °C
2: 94 percent / 1.) boron trifluoride etherate / CH2Cl2 / 1.) 0 deg C, 0.5 h, 2.) 25 deg C, 1.5 h
View Scheme
参考文献
Yadav; Reddy, P. Adi Narayana; Kumar, A. Suman; Prasad; Reddy, B.V. Subba; Al Ghamdi, Ahmad Alkhazim
Tetrahedron Letters, 2014 , vol. 55, # 8 p. 1395 - 1397
反应条件
carbon tetrabromide; Ru(bpy)3Cl2·6H2O; N,N-dimethyl-formamide; sodium bromide
T=25 - 30°C; Inert atmospherevisible-light irradiation;
参考文献
Dai, Chunhui; Narayanam, Jagan M.R.; Stephenson, Corey R.J.
Nature Chemistry, 2011 , vol. 3, # 2 p. 140 - 145
