2-氨基噻唑-4-甲酸乙酯合成路线 （共 34 条）
反应条件
pyridine 6 h; Heating / reflux;
参考文献
Chu, Xin-Jie; Fotouhi, Nader; Huby, Nicholas J.S.; Kong, Norman; McDermott, Lee Apostle; Moliterni, John; Zhang, Zhuming
Patent: US2006/41146 A1, 2006 ;
Location in patent: Page/Page column 15 ;
US 20060041146 A1
反应条件
1: N-bromosuccinimide / acetonitrile / 20 °C 2: CuBr2; isoamylnitrite / acetonitrile / 2 h / 0 °C View Scheme
参考文献
Okonya, John F; Al-Obeidi, Fahad
Tetrahedron Letters, 2002 , vol. 43, # 39 p. 7051 - 7053
反应条件
1: 62 percent / ethanol / 16 h / Heating 2: 70 percent / sodium carbonate / H2O View Scheme
参考文献
Khazi; Koti; Gadad; Mahajanshetti; Shivakumar; Akki
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 2 p. 393 - 398
反应条件
in ethanol 14 h; Heating;
参考文献
Koti, Rajesh; Hegde, Vinayak; Kolavi, Gundurao; Khazi, Imtiyaz Ahmed
Synthetic Communications, 2007 , vol. 37, # 10 p. 1715 - 1722
反应条件
potassium bromide; sodium nitrite in sulfuric acid; water T=-2 - 0°C; 2 h;
参考文献
Houssin, Raymond; Pommery, Jean; Salauen, Marie-Catherine; Deweer, Sophie; Goossens, Jean-Francois; Chavatte, Philippe; Henichart, Jean-Pierre
Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 533 - 536
反应条件
sulfuric acid; sodium bromide; sodium nitrite in water; ethyl acetate
参考文献
Kowa Co., Ltd.
Patent: US6472386 B1, 2002 ;
反应条件
in methanol T=0°C; 1 h; Cooling with ice;
参考文献
Goodnow,, Robert Alan; Huby, Nicholas J.S.; Kong, Norman; McDermott, Lee Apostle; Moliterni, John Anthony; Zhang, Zhuming
Patent: US2006/63814 A1, 2006 ;
Location in patent: Page/Page column 28 ;
US 20060063814 A1
反应条件
1: With sodium methylate in methanol; water T=0°C; 1 h; 2: With ammonium chloride in methanol; water 3: With sodium hydrogencarbonate in methanol; water pH=9;
参考文献
Chu, Xin-Jie; Fotouhi, Nader; Huby, Nicholas J.S.; Kong, Norman; McDermott, Lee Apostle; Moliterni, John; Zhang, Zhuming
Patent: US2006/41146 A1, 2006 ;
Location in patent: Page/Page column 24 ;
US 20060041146 A1
反应条件
1: (bromination) 2: (i) NaNO2, aq. H2SO4, (ii) aq. H3PO2 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 20, p. 572 - 576
反应条件
copper(I) oxide; phosphoric acid in water T=0°C; 1 h;
参考文献
Houssin, Raymond; Pommery, Jean; Salauen, Marie-Catherine; Deweer, Sophie; Goossens, Jean-Francois; Chavatte, Philippe; Henichart, Jean-Pierre
Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 533 - 536
