5-氨基-1-(4-硝基苯基)-1H-吡唑-4-甲腈合成路线 （共 7 条）
反应条件
diethylamine in ethanol RefluxEnzymatic reaction;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; HEISLER, Iring; MÜLLER, Thomas; GOLZ, Stefan; TELSER, Joachim; REHWINKEL, Hartmut; SIEBENEICHER, Holger; BUCHMANN, Bernd; ZORN, Ludwig; EIS, Knut; KOPPITZ, Marcus; LINDNER, Niels; HÉROULT, Mélanie; NEUHAUS, Roland
Patent: WO2013/182612 A1, 2013 ;
Location in patent: Page/Page column 146 ;
反应条件
sodium acetate in ethanol 0.666667 h; Reflux;
参考文献
Dos Santos, Mauricio S.; Gomes, Adriana O.; Bernardino, Alice M. R.; De Souza, Marcos C.; Khan, Misbahul A.; De Brito, Monique A.; Castro, Helena C.; Abreu, Paula A.; Rodrigues, Carlos R.; De Leo, Rosa M. M.; Leon, Leonor L.; Canto-Cavalheirr, Marilene M.
Journal of the Brazilian Chemical Society, 2011 , vol. 22, # 2 p. 352 - 358
反应条件
1: 1.) NaNO2, HCl, 2.) SnCl2, HCl / 1.) H2O, 0 deg C, 2.) H2O, RT, 1 h 2: ethanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 9 p. 2892 - 2898
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 9 p. 2892 - 2898
反应条件
tert.-butylnitrite in tetrahydrofuran 2 h; Reflux;
参考文献
Dos Santos, Mauricio S.; Gomes, Adriana O.; Bernardino, Alice M. R.; De Souza, Marcos C.; Khan, Misbahul A.; De Brito, Monique A.; Castro, Helena C.; Abreu, Paula A.; Rodrigues, Carlos R.; De Leo, Rosa M. M.; Leon, Leonor L.; Canto-Cavalheirr, Marilene M.
Journal of the Brazilian Chemical Society, 2011 , vol. 22, # 2 p. 352 - 358
参考文献
Kreutzberger; Burgwitz
Archiv der Pharmazie, 1981 , vol. 314, # 5 p. 394 - 398
反应条件
1: With acetic anhydride 24 h; Heating; 2: With ammonium hydroxide pH=12 - 13; Further stages.;
参考文献
Gupta, Sanjay; Rodrigues, Ligia M.; Esteves, Ana P.; Oliveira-Campos, Ana M.F.; Nascimento, M. Sao Jose; Nazareth; Cidade, Honorina; Neves, Marta P.; Fernandes, Eduarda; Pinto, Madalena; Cerqueira, Nuno M.F.S.A.; Bras, Natercia
European Journal of Medicinal Chemistry, 2008 , vol. 43, # 4 p. 771 - 780
