N-(4-溴丁基)邻苯二甲酰亚胺合成路线 （共 50 条）
反应条件
in ethanol 18 h; Heating;
参考文献
Karginov, Vladimir A.; Yohannes, Adiamseged; Robinson, Tanisha M.; Fahmi, Nour Eddine; Alibek, Kenneth; Hecht, Sidney M.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 1 p. 33 - 40
反应条件
water; sodium sulfite Kochen des Reaktionsprodukts mit wss.NaOH;
参考文献
Deng, Hong; Liu, Xin; Xie, Jie; Yin, Rong; Huang, Naiyan; Gu, Ying; Zhao, Jingquan
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 1910 - 1919
反应条件
methanol; sodium hydrogensulfide Erwaermen des Reaktionsprodukts mit Hydrazin-hydrat in Aethanol;
参考文献
Bergmann; Kaluszyner
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 289,309
反应条件
potassium carbonate in N-methyl-acetamide; hydrazine hydrate
参考文献
Neurogen Corporation
Patent: US5703237 A1, 1997 ;
US 5703237 A
反应条件
1: 84 percent / AgBF4 / acetonitrile / 20 h / Heating 2: 20-40percent aq. CH3NH2 / 20 h / 30 °C View Scheme
参考文献
Doi, Joyce Takahashi; Luehr, Gary W.
Tetrahedron Letters, 1985 , vol. 26, # 50 p. 6143 - 6146
反应条件
1: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, 100 deg C, 8 h 2: 1.) hydrazine hydrate, 2.) 4 N aq. HCl / 1.) EtOH, reflux, 8 h, 2.) EtOH, reflux, 6 h View Scheme
参考文献
Wright Jr.; Press; Chan; Marsico; Haug; Lucas; Tauber; Tomcufcik
Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 523 - 530
反应条件
in N-methyl-acetamide; potassium carbonate
参考文献
Neurogen Corporation
Patent: US6284759 B1, 2001 ;
US 6284759 B1
反应条件
xylene und Erhitzen des Reaktionsprodukts mit wss. Natronlauge und anschliessend mit wss.Salzsaeure;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/71576 A1, 2009 ;
Location in patent: Page/Page column 21 ;
WO 2009/071576 A1
反应条件
in acetonitrile 24 h; Heating;
参考文献
Wolin; Connolly; Afonso; Hey; She; Rivelli; Willams; West Jr.
Bioorganic and medicinal chemistry letters, 1998 , vol. 8, # 16 p. 2157 - 2162
反应条件
1: ethanol 2: N2H4; aqueous ethanol; aqueous HCl 3: Hydrogenation View Scheme
参考文献
Ashley et al.
Journal of the Chemical Society, 1959 , p. 3880,3882
