(2-氧代-吡咯烷-1-基)-乙酸合成路线 （共 17 条）
参考文献
Justus Liebigs Annalen der Chemie, , vol. 596, p. 1,213
反应条件
sodium hydroxide T=80°C; 1.5 h; Rate constant;
参考文献
Pharmazie, , vol. 44, # 4 p. 272 - 273
反应条件
sodium hydroxide T=80°C; 1.5 h; also with HCl; Rate constant;
参考文献
Pharmazie, , vol. 44, # 4 p. 272 - 273
反应条件
2: 36 percent / Na2CO3 / H2O / 12 h / 0 °C
3: 35 percent / t-BuOK / toluene / 1.5 h / 0 °C
View Scheme
参考文献
Garst, Michael E.; Bonfiglio, John N.; Grudoski, David A.; Marks, Jeffrey
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2307 - 2315
反应条件
2: 36 percent / Na2CO3 / H2O / 12 h / 0 °C
3: 35 percent / t-BuOK / toluene / 1.5 h / 0 °C
4: aq. HCl / 20 h / Heating
View Scheme
参考文献
Garst, Michael E.; Bonfiglio, John N.; Grudoski, David A.; Marks, Jeffrey
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2307 - 2315
反应条件
acetic anhydride
24 h; Heating;
参考文献
Dalla Croce, Piero; La Rosa, Concetta
Heterocycles, 2001 , vol. 55, # 10 p. 1843 - 1857
反应条件
1: 1.) triethylamine, ethyl chloroformate / 1.) chloroform, -5 deg C, 45 min, 2.) -5 deg C, 1.5 h
2: 79 percent / 1.) NH3 / methanol / 1.) 45 deg C, 1 h, 2.) room temp., overnight
View Scheme
参考文献
Valenta, Vladimir; Holubek, Jiri; Svatek, Emil; Valchar, Martin; Krejci, Ivan; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 11 p. 2756 - 2764
