1-二苯甲基氮杂环丁烷-3-甲酸甲酯合成路线 （共 10 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 20.5 h;
参考文献
Eisai RandD Management Co., Ltd.
Patent: US2008/214815 A1, 2008 ;
Location in patent: Page/Page column 14 ;
反应条件
sulfuric acid in methanol
参考文献
Shionogi and Co., Ltd.
Patent: US4200628 A1, 1980 ;
反应条件
1: With sulfuric acid 1 h; Reflux; 2: With sodium hydrogencarbonate in chloroform; water
参考文献
US2010/249399 A1, ;
Page/Page column 21 ;
反应条件
sulfuric acid T=90°C; 2 h;
参考文献
Morley, Andrew; Tomkinson, Nicholas; Cook, Andrew; MacDonald, Catherine; Weaver, Richard; King, Sarah; Jenkinson, Lesley; Unitt, John; McCrae, Christopher; Phillips, Tim
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 20 p. 6031 - 6035
反应条件
1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 2: water; N,N-dimethyl-formamide / 90 °C 3: sulfuric acid / 2 h / 90 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 20 p. 6031 - 6035
反应条件
1: water; N,N-dimethyl-formamide / 90 °C 2: sulfuric acid / 2 h / 90 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 20 p. 6031 - 6035
反应条件
1: ethanol / 144 h / 20 °C / Reflux 2: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 3: water; N,N-dimethyl-formamide / 90 °C 4: sulfuric acid / 2 h / 90 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 20 p. 6031 - 6035
反应条件
sodium hydroxide in tetrahydrofuran; methanol
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US5102877 A1, 1992 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 3.66667 h; 2: With sodium hydroxide; water in tetrahydrofuran T=0°C; 0.333333 h;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP1961750 A1, 2008 ;
Location in patent: Page/Page column 78-79 ;
反应条件
hydrogenchloride; hydrogen; palladium(II) hydroxide/carbon in methanol; ethyl acetate T=20°C; P=3000.3 Torr; 11 h;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP1889836 A1, 2008 ;
Location in patent: Page/Page column 80 ;
