2-甲基吲哚-3-羧酸乙酯合成路线 （共 28 条）
反应条件
sulfuric acid T=-10 - 15°C; 3 h;
参考文献
Janssen RandD Ireland; Cooymans, Ludwig Paul; Demin, Samuël Dominique; Hu, Lili; Jonckers, Tim Hugo Maria; Raboisson, Pierre Jean-Marie Bernard; Tahri, Abdellah; Vendeville, Sandrine Marie Helene
Patent: US2013/267555 A1, 2013 ;
Location in patent: Paragraph 0168; 0171-0173 ;
反应条件
copper(I) oxide; caesium carbonate in water; dimethyl sulfoxide T=100°C; 9 h; Inert atmosphere; regiospecific reaction;
参考文献
Ali, Md Ashif; Punniyamurthy, Tharmalingam
Synlett, 2011 , # 5 art. no. D26210ST, p. 623 - 626
反应条件
copper diacetate; palladium diacetate; potassium carbonate in N,N-dimethyl-formamide T=140°C; 0.25 h; Inert atmosphere;
参考文献
Neumann, Julia J.; Rakshit, Souvik; Droege, Thomas; Wuertz, Sebastian; Glorius, Frank
Chemistry - A European Journal, 2011 , vol. 17, # 26 p. 7298 - 7303
反应条件
1: methylenecarboxanilide With alpha-chloropyridine; 2,6-Dichloropyridine; trifluoromethylsulfonic anhydride in dichloromethane T=-78 - 0°C; Inert atmosphere; 2: diazoacetic acid ethyl ester in dichloromethane T=-30°C; 0.333333 h; Inert atmosphere;
参考文献
Cui, Sun-Liang; Wang, Jing; Wang, Yan-Guang
Journal of the American Chemical Society, 2008 , vol. 130, # 41 p. 13526 - 13527
反应条件
triethylamine; tris-(o-tolyl)phosphine; palladium diacetate in N,N-dimethyl-formamide T=120°C;
参考文献
Sakamoto, Takao; Nagano, Tatsuo; Kondo, Yoshinori; Yamanaka, Hiroshi
Synthesis, 1990 , # 3 p. 215 - 218
反应条件
triethylamine; palladium diacetate in N,N-dimethyl-formamide T=120°C; 8 h;
参考文献
Sakamoto, Takao; Nagano, Tatsuo; Kondo, Yoshinori; Yamanaka, Hiroshi
Synthesis, 1990 , # 3 p. 215 - 218
反应条件
copper(l) iodide in N,N-dimethyl-formamide T=120°C;
参考文献
US2008/4309 A1, ;
Page/Page column 31 ;
反应条件
lithium tert-butylate in tert-butyl alcohol T=82°C;
参考文献
Dijkink, Jan; Zonjee, Johannes N.; Jong, Bart S. de; Speckamp, W. Nico
Heterocycles, 1983 , vol. 20, # 7 p. 1255 - 1258
反应条件
tetrakis(triphenylphosphine) palladium(0); silver orthophosphate in dimethyl sulfoxide T=100°C; Heck reaction; 3.5 h;
参考文献
Tetrahedron, , vol. 65, # 7 p. 1327 - 1335
反应条件
1: 82 percent / TsOH / benzene / Heating 2: 73 percent / Et3N / Pd(OAc)2 / dimethylformamide / 8 h / 120 °C View Scheme
参考文献
Synthesis, , # 3 p. 215 - 218
