4-溴-N-(二苯亚甲基)苯胺合成路线 （共 14 条）
反应条件
tris(dibenzylideneacetone)dipalladium (0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate in tetrahydrofuran Heating;
参考文献
Zhang, Xiao-Xiang; Sadighi, Joseph P.; Mackewitz, Thomas W.; Buchwald, Stephen L.
Journal of the American Chemical Society, 2000 , vol. 122, # 31 p. 7606 - 7607
反应条件
hydrogenchloride in tetrahydrofuran Yield given;
参考文献
Tetrahedron Letters, , vol. 38, # 36 p. 6367 - 6370
反应条件
1: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 30 min, 2.) hexane, THF, RT, 45 min 2: H2NOH*HCl, KHCO3 / methanol / 0.5 h View Scheme
参考文献
Sadighi, Joseph P.; Singer, Robert A.; Buchwald, Stephen L.
Journal of the American Chemical Society, 1998 , vol. 120, # 20 p. 4960 - 4976
反应条件
AlCl3, aluminium chloride; triethylamine in chloroform
T=20°C; 3 h;
参考文献
Liu, Yan; Yang, Qiwu; Hao, Dongling; Zhang, Wenqin
Australian Journal of Chemistry, 2012 , vol. 65, # 10 p. 1390 - 1395,6
反应条件
2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) in toluene
T=80°C; 20 h;
参考文献
Larsen, Simon Birkso; Bang-Andersen, Benny; Johansen, Tommy Norskov; Jorgensen, Morten
Tetrahedron, 2008 , vol. 64, # 13 p. 2938 - 2950
反应条件
n-butyllithium in tetrahydrofuran; hexane
T=-75°C; 1 h;
参考文献
Theodorou, Vassiliki; Skobridis, Konstantinos; Karkatsoulis, Aris
Tetrahedron, 2007 , vol. 63, # 20 p. 4284 - 4289
反应条件
1: n-BuLi / tetrahydrofuran / 1 h / -75 °C
2: Heating
View Scheme
参考文献
Theodorou, Vassiliki; Skobridis, Konstantinos; Karkatsoulis, Aris
Tetrahedron, 2007 , vol. 63, # 20 p. 4284 - 4289
反应条件
1.1: magnesium
1.2: diethyl ether / 1 h / Heating
2.1: thionyl chloride / CCl4 / 5 h / 20 °C
3.1: ammonium hydroxide / CH2Cl2; H2O / 48 h
4.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -75 °C
View Scheme
参考文献
Theodorou, Vassiliki; Skobridis, Konstantinos; Karkatsoulis, Aris
Tetrahedron, 2007 , vol. 63, # 20 p. 4284 - 4289
反应条件
1.1: magnesium
1.2: diethyl ether / 1 h / Heating
2.1: thionyl chloride / CCl4 / 5 h / 20 °C
3.1: ammonium hydroxide / CH2Cl2; H2O / 48 h
4.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -75 °C
View Scheme
参考文献
Theodorou, Vassiliki; Skobridis, Konstantinos; Karkatsoulis, Aris
Tetrahedron, 2007 , vol. 63, # 20 p. 4284 - 4289
反应条件
1: ammonium hydroxide / CH2Cl2; H2O / 48 h
2: n-BuLi / tetrahydrofuran; hexane / 1 h / -75 °C
View Scheme
参考文献
Theodorou, Vassiliki; Skobridis, Konstantinos; Karkatsoulis, Aris
Tetrahedron, 2007 , vol. 63, # 20 p. 4284 - 4289
