titanium tetrachloride in nitromethane T=20°C; 100 h;

1: With n-butyllithium; diisopropylamine in tetrahydrofuran T=-78 - 0°C; 0.166667 h; 2: 2-hydroxy-4,5-dimethylacetophenone in tetrahydrofuran T=-78°C; 0.75 h; 3: methyl iodide in tetrahydrofuran T=20°C;

water in ethanol 0.25 h; Heating;

1: 95 percent / pyridine / 24 h / Heating 2: 99 percent / TiCl4 / nitromethane / 100 h / 20 °C View Scheme

aluminium trichloride T=120 - 150°C;